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Preparation method of traditional Chinese medicine granular preparation

A technology of traditional Chinese medicine granules and preparations, which is applied in the field of preparation of traditional Chinese medicine granules. It can solve the problems of long drying time, large amount of ethanol consumption, and poor particle formation, so as to reduce production energy consumption, shorten drying time, and shorten the process. cycle effect

Pending Publication Date: 2021-11-30
陕西健民制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, wet granulation, when the wetting agent used is ethanol, has a large amount of ethanol consumption, long drying time, poor granule formation, and low product yield
Dry granulation is for traditional Chinese medicine preparations, mainly because there are many fine powders and large dust in the dry granules.

Method used

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  • Preparation method of traditional Chinese medicine granular preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0028] A preparation method of traditional Chinese medicine granules, comprising the following steps:

[0029] (1) Preparation of ethanol solution: use 95% ethanol as raw material to prepare an ethanol solution with a volume concentration of 70%;

[0030] (2) Pre-compression treatment: the extract obtained by extracting the raw materials of traditional Chinese medicine granules, drying at 60±10°C for 10±2 hours, crushing and passing through a 100-mesh sieve to obtain a dry paste fine powder, the dry paste The fine powder is placed in a dry granulator and extruded into granules, passed through a 12-60 mesh sieve to obtain pretreated granules, and the rest of the granules are returned to the dry granulator; the process conditions of the dry granulator are as follows: The stirring speed is 25-40r / min, the feeding speed is 150-230r / min, the feeding load is 4.5-5.0Amp, the pressure roller spacing is 0.5-1.5mm, the pressure roller speed is 30-45r / min, the pressure roller load is 8-1...

Embodiment 2

[0042] Take the preparation of Yigong Granules as an example to prepare dry cream powder:

[0043] (a) The traditional Chinese medicine raw materials of Yigong Granules are as follows: 236 parts of Astragalus, 198 parts of Angelica, 236 parts of Chuandu, 198 parts of Codonopsis, 198 parts of Motherwort, 118 parts of Salvia, 198 parts of Patrinia, and 118 parts of Cyperus;

[0044] (b) Preparation of extract:

[0045] Take Salvia miltiorrhiza, add 8 times the amount of 50% ethanol, extract 3 times, each time for 1 hour, filter, combine the filtrate, recover ethanol under reduced pressure, concentrate to a relative density of 1.25 (70-75°C), clear the paste, and set aside;

[0046] Take angelica and Cyperus cyperi and crush them into 40-60 mesh coarse powder, extract volatile oil by steam distillation, and decoct in water for later use;

[0047] Take the volatile oil and use β-cyclodextrin for inclusion to obtain the inclusion;

[0048] Astragalus, Chuandian, Codonopsis, Mothe...

Embodiment 3

[0051] A preparation method of traditional Chinese medicine granules, comprising the following steps:

[0052] (1) Preparation of ethanol solution: use 95% ethanol as raw material to prepare an ethanol solution with a volume concentration of 70%;

[0053] (2) Pre-compression treatment: Take 100 kg of the dry paste fine powder prepared in the above-mentioned Example 2 and place it in a dry granulator to extrude the fine powder mixture into granules, pass through a 12-mesh sieve and a 60-mesh sieve in turn to obtain the pre-pressed powder. The processed granules and the remaining granules are returned to the dry granulator; the process conditions of the dry granulator (Nanjing Canaan Bison Technology Co., Ltd., model: LG200) are as follows: stirring speed 35r / min, feeding speed 170r / min min, feeding load 4.5Amp, pinch wheel spacing 0.8mm, pinch wheel speed 37r / min, pinch wheel load 8Amp, crushing speed 110r / min, whole grain speed 140r / min, water temperature of upper pinch wheel ...

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Abstract

The invention discloses a preparation method of a traditional Chinese medicine granular preparation. The preparation method comprises the following steps: (1) preparing an ethanol solution; (2) pre-compressing treatment: extracting raw materials of the traditional Chinese medicine granular preparation to obtain extract, conducting drying and crushing, sieving with a 100 mesh sieve to obtain dry paste fine powder, putting the dry paste fine powder into a dry granulator for compressing into granules, sieving with a 12-60 mesh sieve to obtain pre-treated granules, and returning the remaining granules to the dry granulator; (3) mixing in a trough type mixer and drying: putting the pretreated granules into a trough type mixer, then adding the ethanol solution in the step (1), stirring for 10 minutes, and then drying at 75 + / -5 DEG C for 5 + / -1 hour; and (4) granulating: sieving the granules obtained in the step (3) with a 12 mesh sieve, and sealing and storing. The method provided by the invention reduces usage of ethanol, shortens drying time, reduces production energy consumption, shortens technological period of granulation procedure, and improves product yield.

Description

technical field [0001] The invention belongs to the technical field of preparation of traditional Chinese medicines, and in particular relates to a preparation method of traditional Chinese medicine granule preparations. Background technique [0002] Regarding the preparation method of traditional Chinese medicine granule preparation, dry granulation or wet granulation is generally adopted. [0003] Dry granulation is a method of uniformly mixing the powders of drugs and excipients, compressing them into large flakes or plates, and then pulverizing them into particles of the required size. This method relies on compressive force to generate binding force between molecules, and its preparation methods include tableting method and rolling method. The dry granulation and tabletting method is often used for heat-sensitive materials and drugs that are easily decomposed when exposed to water. The method is simple and saves labor and time. [0004] Wet granulation is a method in ...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K36/8905A61K47/10A61P15/00
CPCA61K9/1682A61K36/481A61K36/232A61K36/185A61K36/344A61K36/533A61K36/537A61K36/84A61K36/8905A61K9/1617A61P15/00A61K2236/333A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2300/00
Inventor 郭楠李宗武
Owner 陕西健民制药有限公司
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