Bimetal MOF catalyst for synthesizing cyclic lactone by tandem catalysis of cyclic alcohol as well as preparation method and application of bimetal MOF catalyst

Abstract

The invention relates to a bimetallic MOF catalyst for synthesizing cyclic lactone by tandem catalysis of cyclic alcohol as well as a preparation method and application of the bimetal MOF catalyst. The bimetallic in the bimetallic MOF catalyst is selected from any two of Mg, Mn, Fe, Co, Ni, Cu or Zn, and an organic ligand is selected form one or a combination of at least two of 2-hydroxyterephthalic acid, 2, 5-dihydroxyterephthalic acid, 3-hydroxy-4, 4-diphenyldicarboxylic acid or 3, 3-dihydroxy-4, 4-diphenyldicarboxylic acid. the bimetallic MOF catalyst disclosed by the invention is used for preparing the cyclic lactone by 'one-pot ' tandem catalysis of the cyclic alcohol, and has the advantages of high reaction rate, mild reaction conditions, high yield and selectivity of the cyclic lactone and universality.

Description

technical field [0001] The invention belongs to the field of catalytic synthesis, and relates to a bimetallic MOF catalyst for catalyzing ring alcohols to synthesize ring lactones in series, a preparation method and application thereof. Background technique [0002] The preparation of cyclic lactones is a valuable reaction in organic synthesis, which has many possible applications, for example, the synthesis of expensive intermediates or products such as antibiotics, steroids, pheromones, and polymerized monomers. [0003] At present, the most reliable class of reactions for the preparation of cyclic lactones is to synthesize cyclic ketones from cyclic ketones by Baeyer-Villiger Oxidation (Baeyer-Villiger Oxidation); however, this reaction usually requires the use of hydrogen peroxide Strong oxidizing agents such as peroxyacids (such as peracetic acid, trifluoroperoxyacetic acid, and m-chloroperoxybenzoic acid) are used as oxidizing agents, which are explosive hazards and ar...

AI Technical Summary

Problems solved by technology

[0003] At present, the most reliable class of reactions for the preparation of cyclic lactones is to synthesize cyclic ketones from cyclic ketones by Baeyer-Villiger Oxidation (Baeyer-Villiger Oxidation); however, this reaction usually requires the use of hydrogen peroxide Strong oxidizing agents such as peroxyacids (such as peracetic acid, trifluoroperoxyacetic acid, and m-chloroperoxybenzoic acid) are used as oxidizing agents, which are explosive hazards and are usually very expensive (see literature: R.A.Sheldon et al. The Baeyer-Villiger Reaction: New Developments toward Greener Procedures.Chem.Rev., 2004,104,4105-4123.); Avelino Corma et al. in dioxane solvent, with H 2 o 2 (35%) as an oxidant, using Sn-β molecular sieve as a catalyst to catalyze the oxidation of cyclohexanone, after reacting for 3 hours at 90°C, the yield of cyclohexanolactone reached 52% (see literature: Avelino Corma et al. "Sn -zeolite beta as a heterogeneous chemoselective catalyst for Baeyer-Villiger oxidations."Nature, 2001, 412(6845), 423-425.)

In the preparation process of cyclic ketones, especially cyclohexanone, the formation of cyclohexanol is usually unavoidable. However, there are few reports on the synthesis method of directly preparing the corresponding cyclic lactones by using cyclic alcohols as raw materials through a heterogeneous catalytic oxidation process.