Smoke exposure experiment device

Abstract

The invention discloses a smoke exposure experiment device which comprises an experiment bin and a cover body arranged on the outer side of the experiment bin in a covering mode, wherein a flat plate is arranged in the experiment bin, and the experiment bin is divided into an animal bin and a combustion bin through the flat plate; at least one partition plate is arranged above the flat plate and divides the animal bin into at least two animal experiment areas; a plurality of through holes are formed in the bin wall of the experiment bin and the flat plate respectively; the cover body is provided with a smoke exhaust pipe, and the smoke exhaust pipe is connected with a negative pressure generating device; the cover body is further provided with a one-way ventilation device, so that air outside the cover body flows into the cover body in a one-way mode. The smoke exposure experiment device provided by the invention is simple in structure and convenient to operate, and can effectively prevent effect differences caused by gathering of experimental animals, so that intra-group differences are reduced, and inter-group emphysema differences are evaluated more effectively.

Description

technical field [0001] The present application relates to the technical field of experimental devices, in particular to an experimental device for smoke exposure. Background technique [0002] Chronic obstructive pulmonary disease (COPD, Chronic Obstructive Pulmonary Disease, COPD) is a life-threatening progressive chronic respiratory disease mainly caused by cigarette smoke, mainly manifested as irreversible airflow limitation. COPD is now the third leading cause of death worldwide, according to the World Health Organization. Because there is currently no cure for COPD, clinically, symptomatic treatment is the mainstay. Therefore, it is necessary to further explore the pathogenesis of COPD at the molecular level in order to find effective therapeutic targets. Emphysema is the main pathological feature of COPD, and it is also the focus and focus of research on the pathogenesis of COPD. COPD-related human experiments are limited due to ethical issues, and the study of its m...

AI Technical Summary

Problems solved by technology

[0004] There are special animal smoking devices on the market, which are precise and easy to use, but the price is nearly 100,000 yuan, which is relatively expensive, and a single cigarette smoke generating device also costs tens of thousands of yuan. The initial investment in purchasing such precision devices is too large, and the cost performance is not high

At the same time, some simple fumigation devices invented in the past have exhausted the smoke and have not recycled it to enter the research environment. There are defects such as indoor air pollution that causes researchers to passively inhale second-hand smoke.

[0005] And in the existing experimental devices for smoke exposure, most of the animals are placed in a large box or directly placed in animal cages, and there is no partition inside.

During the research process, the applicant found that the animals would gather in piles during the exposure to cigarette smoke or other harmful gases in the large box, and the contact between mouth, nose and air was limited to a certain extent, resulting in the inability of some animals to have effective and uniform exposure to smoke. The above-mentioned defects will affect the identity and stability of the experimental results. Even the pathological damage of emphysema caused by the same batch of mice has large intra-group differences, which makes it impossible for researchers to truly evaluate the differences between groups. Differences in emphysema greatly increase the risk of emphysema in knockout mice and the efficacy of emphysema in mice treated with certain drug interventions

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