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Preparation method of citrus pectin iron as well as product and application of citrus pectin iron

A technology of pectin and citrus, which is applied in the field of drug preparation, can solve undiscovered problems and achieve a good effect of iron supplementation

Active Publication Date: 2021-11-09
GUILIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no relevant report on the preparation of polysaccharide iron from citrus pectin

Method used

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  • Preparation method of citrus pectin iron as well as product and application of citrus pectin iron
  • Preparation method of citrus pectin iron as well as product and application of citrus pectin iron
  • Preparation method of citrus pectin iron as well as product and application of citrus pectin iron

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of citrus pectin iron comprises the following steps:

[0031] According to the mass ratio of 3:1, 4:1, 5:1, 6:1, 7:1, weigh citrus pectin and sodium citrate, dissolve in distilled water, heat in a water bath at 40°C and stir evenly. Slowly add 2mol / L FeCl dropwise 3 solution, and use 20wt% NaOH solution to adjust the pH value of the solution to 2.0, and control the pH of the reaction system to be 2.0. Stop adding FeCl dropwise when a reddish-brown insoluble precipitate appears in the solution 3 solution and NaOH solution, then continue heating in a water bath at 40°C for 1 hour, centrifuge at a speed of 4500 r / min for 10 minutes and separate the supernatant, use a dialysis bag with a molecular weight cut-off of 3500 to dialyze the supernatant for 24 hours, concentrate the solution obtained by dialysis, Freeze-dry to obtain citrus pectin iron solid.

[0032] Determination of iron content in citrus pectin iron:

[0033] (1) Standard curve drawing

[0...

Embodiment 2

[0040] The preparation of citrus pectin iron, the steps are as follows:

[0041] Weigh citrus pectin and sodium citrate at a mass ratio of 5:1, dissolve them in distilled water, divide the solution into 5 parts, heat them in water baths at 20°C, 30°C, 40°C, 50°C and 60°C, and stir them evenly. Slowly add 2mol / L FeCl dropwise 3 solution, and adjust the pH value of the solution to 2.0 with 20% wt NaOH solution, and control the pH of the reaction system to be 2.0. Stop adding FeCl dropwise when a reddish-brown insoluble precipitate appears in the solution 3 solution and NaOH solution, and then continue to heat in a water bath environment at the corresponding temperature for 1 hour, then centrifuge at a speed of 4500r / min for 10 minutes and separate the supernatant, and use a dialysis bag with a molecular weight cut-off of 3500 to dialyze the supernatant for 24 hours. The resulting solution was concentrated and freeze-dried to obtain ferric citrus pectin as a solid.

[0042] Ac...

Embodiment 3

[0044] The preparation of citrus pectin iron, the steps are as follows:

[0045] Weigh citrus pectin and sodium citrate at a mass ratio of 5:1, dissolve in distilled water, divide the solution into 8 parts, heat in a water bath at 40°C and stir evenly. Use 20wt% NaOH solution to adjust the pH of each solution to 1.0, 2.0, 3.0, 4.0, 5.0, and then add 2.0mol / L FeCl dropwise 3 Solution reaction, add 20wt% NaOH solution at the same time to keep the pH of the system at 1.0, 2.0, 3.0, 4.0, 5.0 during the reaction, stop adding FeCl dropwise when reddish-brown insoluble precipitates appear in the solution 3 solution and NaOH solution, then continue heating in a water bath at 40°C for 1 hour, centrifuge at a speed of 4500 r / min for 10 minutes and separate the supernatant, use a dialysis bag with a molecular weight cut-off of 3500 to dialyze the supernatant for 24 hours, concentrate the solution obtained by dialysis, Freeze-dry to obtain citrus pectin iron solid.

[0046] According to...

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Abstract

The invention discloses a preparation method of citrus pectin iron and a product and application of the citrus pectin iron, and belongs to the technical field of medicine preparation.The preparation method comprises the following steps that citrus pectin and sodium citrate are dissolved in water and heated, a FeCl3 solution is dropwise added for a reaction, the pH of a reaction system is controlled to range from 1.5 to 4, dropwise adding of the FeCl3 solution is stopped when reddish brown precipitates appear, after heat preservation, centrifugal separation is performed to obtain supernate, and the obtained supernate is dialyzed, concentrated and freeze-dried to obtain the citrus pectin iron. The iron element and the citrus pectin are compounded to obtain the citrus pectin iron with relatively high iron content, so that the citrus pectin iron has the effects of resisting oxidation, scavenging free radicals and resisting aging of the citrus pectin, also has a good iron supplementing effect, and can be used for preparing medicines and health-care products for supplementing iron, scavenging free radicals, resisting oxidation and resisting aging; the invention provides a reference basis for the application of the citrus pectin iron in the fields of medicines and health care products.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a preparation method of citrus pectin iron and its product and application. Background technique [0002] Citrus pectin is a natural acidic polysaccharide that is mainly extracted from the pulp and peel of citrus fruits such as lemons, oranges, grapefruits, etc. Citrus pectin is one of the main types of commercial pectin, mostly white or light yellow powder, with a molecular weight of 50,000-300,000 Da, composed of 150-500 D-pyrans through α-1,4-glucosidic bonds Linked by galacturonic acid. Generally, there are at least four structures in pectin, which are homogalacturonan, rhamnogalacturonan I, rhamnogalacturonan II and xylogalacturonan. Citrus pectin belongs to soluble dietary fiber, which is a natural human dietary component and is beneficial to human health. Citrus pectin has various biological activities, such as anti-oxidation, anti-inflammation,...

Claims

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Application Information

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IPC IPC(8): C08B37/06A61K31/732A61K33/26A61P3/02A61P39/06
CPCC08B37/0045A61K33/26A61K31/732A61P3/02A61P39/06Y02A50/30
Inventor 关媛汤霞利董雪晨李静
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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