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Application of quinoline derivative in preparation of medicine for treating diabetes and complications thereof

A technology of derivatives and quinolines, which is applied in the field of application of quinoline derivatives in the preparation of drugs for the treatment of diabetes and its complications, can solve the problems of low cure rate of diabetic complications, achieve the purpose of enhancing kidney function, inhibiting cell Death, the effect of improving renal function

Active Publication Date: 2021-11-05
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently available hypoglycemic drugs have a low cure rate for diabetic complications, and most patients need life-long medication to control blood sugar

Method used

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  • Application of quinoline derivative in preparation of medicine for treating diabetes and complications thereof
  • Application of quinoline derivative in preparation of medicine for treating diabetes and complications thereof
  • Application of quinoline derivative in preparation of medicine for treating diabetes and complications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] The impact of embodiment 1 primaquine phosphate on diabetes

[0064] 1. Establishment and grouping of C57BL / 6N mouse diabetes model

[0065] 1.1 Model establishment

[0066] Seventy C57BL / 6N mice were randomly divided into three groups, namely, normal diet group (20 rats), high-fat diet group (20 rats), and high-fat diet+STZ group (30 rats).

[0067] Mice in the normal feed group: After being fed with the normal feed for three weeks, they were continuously injected with an equal volume of citric acid buffer solution for 5 days, and then continued to be fed with the normal feed until the modeling was completed;

[0068] Mice in the high-fat diet group: After being fed with high-fat diet for three weeks, they were continuously injected with an equal volume of citric acid buffer solution for 5 days, and then continued to be fed with high-fat diet until the end of modeling;

[0069] Mice in the high-fat diet+STZ group: After being fed with high-fat diet for three weeks, i...

Embodiment 2

[0105] The effect of embodiment 2 quinine on diabetic mice

[0106] 1. Establishment and grouping of C57BL / 6N mouse diabetes model

[0107] 1.1 Model establishment

[0108] The 30 mice were randomly divided into two groups: normal diet group (6 rats), high-fat diet+STZ group (24 rats); other operations were the same as in Example 1.

[0109] 1.2 Grouping

[0110] When the fasting blood glucose of the mice in the high-fat diet+STZ group (without food and water for 12 hours, blood glucose was measured at 7:30pm-9:00pm) was higher than 15mmol / L, it could be considered as a successful type 2 diabetes model. After the experiment officially started, all mice were fed with normal feed. Wherein high-fat diet+STZ group mouse model mice were divided into three groups (model group, model+metformin hydrochloride group and model+quinine group), common diet group mice were divided into one group (common diet group), a total of 4 Groups, 6 in each group, as follows:

[0111] a. Model gr...

Embodiment 3

[0122] The effect of embodiment 3 quinacrine on diabetic mice

[0123] 1. Establishment and grouping of C57BL / 6N mouse diabetes model

[0124] 1.1 Model establishment

[0125] The 30 mice were randomly divided into two groups: normal diet group (6 rats), high-fat diet+STZ group (24 rats); other operations were the same as in Example 1.

[0126] 1.2 Grouping

[0127] When the fasting blood glucose of the mice in the high-fat diet+STZ group (without food and water for 12 hours, blood glucose was measured at 7:30pm-9:00pm) was higher than 15mmol / L, it could be considered as a successful type 2 diabetes model. After the experiment officially started, all mice were fed with normal feed. Among them, the high-fat diet+STZ group mouse model mice were divided into three groups (model group, model+metformin hydrochloride group and model+quinacrine dihydrochloride group), and the mice in the common diet group were divided into one group (common diet group), a total of 4 groups with 9...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to application of a quinoline derivative in preparation of medicine for treating diabetes and complications thereof. The invention provides the quinoline derivative, particularly new application of clinically common antimalarial or antiprotozoal medicine such as primaquine phosphate, quinine and quinacridine dihydrochloride in treatment of diabetes. The quinoline derivative is new use of conventional medicine, and can accelerate clinical tests; the quinoline derivative can interfere with the synthesis of DNA, resists immune cell death caused by viruses, maintains immunity, effectively reduces blood sugar at the same time, improves renal functions, and reduces cardiovascular and cerebrovascular disease indexes such as triglyceride, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol; and the curative effect of the quinoline derivative is about 200 times that of existing clinical medicine metformin, and the quinoline derivative is expected to cure type 2 diabetes, so that a patient does not take the medicine all the time, and the quinoline derivative has a wide application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of quinoline derivatives in the preparation of medicines for treating diabetes and its complications. Background technique [0002] Diabetes mellitus is a metabolic disease characterized by hyperglycemia caused by defects in insulin secretion or its biological action. According to the latest global diabetes map released by the International Diabetes Federation (IDF), the number of diabetic patients worldwide reached 425 million by the end of 2017, and it is estimated that by 2045, the number of global diabetic patients will reach 629 million, showing a continuous upward trend in global diabetic patients. Diabetes can be divided into two types: type 1 diabetes and type 2 diabetes according to the patient's age of onset, onset symptoms and treatment drugs. Type 1 diabetes is insulin-dependent diabetes, autoimmune reaction damages pancreatic islet B cells, insuli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4709A61K31/47A61K31/473A61P3/10A61P13/12A61P1/02A61P9/00A61P17/02A61P9/14A61P9/10
CPCA61K31/4709A61K31/47A61K31/473A61P3/10A61P13/12A61P1/02A61P9/00A61P17/02A61P9/14A61P9/10
Inventor 陈新平吴桐雨李纯李响响
Owner LANZHOU UNIVERSITY
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