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Membrane-coated drug-loaded microspheres, drug-sustained-release parasite-expelling pet collar and preparation method thereof

A drug-loaded microsphere and membrane-coated technology, applied in botany equipment and methods, animal repellants, chemicals for biological control, etc., to achieve good drug loading performance, good affinity and compatibility , Good effect of plasticizing processing

Active Publication Date: 2021-11-02
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problems of repelling insects, safety, drug sustained release speed, shelf life and suitable drug-loaded mesoporous silicon of insect repellent pet collars, the present invention provides a membrane-coated drug-loaded microsphere and drug sustained-release insect repellent Pet collar and preparation method thereof

Method used

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  • Membrane-coated drug-loaded microspheres, drug-sustained-release parasite-expelling pet collar and preparation method thereof
  • Membrane-coated drug-loaded microspheres, drug-sustained-release parasite-expelling pet collar and preparation method thereof
  • Membrane-coated drug-loaded microspheres, drug-sustained-release parasite-expelling pet collar and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Include by weight: 67.7 parts by weight of polyvinyl chloride, 22 parts by weight of film-coated drug-loaded microspheres, 3 parts by weight of dispersant, 0.3 parts by weight of antioxidant, 1 part by weight of stabilizer, 5 parts by weight of reinforcing agent, 1 part by weight of parts by weight additive;

[0063] The preparation steps of the deworming pet collar are as follows:

[0064] (1) Add 67.7 parts by weight of polyvinyl chloride to the mixing equipment, then add 3 parts by weight of dispersant, mix and disperse at room temperature for 15 minutes; then add 1 part by weight of stabilizer and 0.3 parts by weight of antioxidant, and mix and disperse for 10 minutes at room temperature; Add 22 parts by weight of film-coated drug-loaded microspheres, 5 parts by weight of enhancer and 1 part by weight of additives, set the temperature at 45°C, mix and disperse for 10 minutes, and obtain a uniform mixture for use;

[0065] (2) Add the homogeneous mixture obtained in...

Embodiment 2

[0070] Include by weight: 66.7 parts by weight of polyvinyl chloride, 22 parts by weight of film-coated drug-loaded microspheres, 3 parts by weight of dispersant, 0.3 parts by weight of antioxidant, 1 part by weight of stabilizer, 5 parts by weight of reinforcing agent, 2 parts by weight of parts by weight additive;

[0071] The preparation steps of the deworming pet collar are as follows:

[0072] (1) Add 66.7 parts by weight of polyvinyl chloride to the mixing equipment, then add 3 parts by weight of dispersant, mix and disperse at room temperature for 15 minutes; then add 1 part by weight of stabilizer and 0.3 parts by weight of antioxidant, and mix and disperse for 10 minutes at room temperature; Add 22 parts by weight of film-coated drug-loaded microspheres, 5 parts by weight of enhancer and 2 parts by weight of additives, set the temperature at 45°C, mix and disperse for 10 minutes, and obtain a uniform mixture for use;

[0073](2) Add the homogeneous mixture obtained i...

Embodiment 3

[0078] Include by weight: 65.7 parts by weight of polyvinyl chloride, 22 parts by weight of film-coated drug-loaded microspheres, 3 parts by weight of dispersant, 0.3 parts by weight of antioxidant, 1 part by weight of stabilizer, 5 parts by weight of reinforcing agent, 3 parts by weight of parts by weight additive;

[0079] The preparation steps of the deworming pet collar are as follows:

[0080] (1) Add 65.7 parts by weight of polyvinyl chloride to the mixing equipment, then add 3 parts by weight of dispersant, mix and disperse at room temperature for 15 minutes; then add 1 part by weight of stabilizer and 0.3 parts by weight of antioxidant, and mix and disperse for 10 minutes at room temperature; Add 22 parts by weight of film-coated drug-loaded microspheres, 5 parts by weight of enhancer and 3 parts by weight of additives, set the temperature at 45°C, mix and disperse for 10 minutes, and obtain a uniform mixture for use;

[0081] (2) Add the homogeneous mixture obtained ...

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Abstract

The invention discloses membrane-coated drug-loaded microspheres. Microcrystalline cellulose, organic calcium and bis (2-ethylhexyl) sodium sulfosuccinate are adopted as pore-forming agents of macroporous porous silicon, mesoporous or hollow or three-dimensional penetrating porous silicon dioxide is obtained after calcination, then acidizing treatment is conducted through hydrochloric acid, calcium in a silicon-calcium skeleton is dissolved and removed, and macroporous and three-dimensionally penetrated porous silica is obtained, the porous silicon framework and the surface of the porous silicon are very rough, pits and grooves are very rich, and loading and adhesion of drugs are facilitated. Besides, a drug-sustained-release parasite-expelling pet collar is prepared by using the membrane-coated drug-loaded microspheres so that the obtained pet collar has a good parasite-expelling effect, a long-acting sustained-release effect and a good quality guarantee effect. The product technology is mature, the production operation is simple and easy to understand, and the production cost is relatively reasonable.

Description

technical field [0001] The invention relates to the technical fields of synthesis of nanomaterials, drug sustained release and composite materials thereof, and in particular to a film-coated drug-loaded microsphere, drug sustained-release insect repellent pet collar and a preparation method thereof. Background technique [0002] With the continuous improvement of living standards, more and more pets have entered thousands of households, exerting their own unique value and meeting the needs of family owners in certain aspects. As pets spend more and more time with their owners, they will gradually develop emotions, and even treat pets as members of the family. Therefore, more and more attention will be paid to the health of pets. At present, pets are limited by factors such as feeding conditions and feeding habits. More or less parasites, such as mites, worms, fleas, lice, etc., will appear on pets, causing loss of appetite, weight loss, and poor spirits. And the owner has b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/26A01N25/08A01N25/22A01N37/52A01N25/00A01P17/00C08L27/06C08L91/00C08L1/04C08K9/12C08K5/29C08K9/10C08K9/06C08K7/26C08K5/098C08K5/11C08K5/103C08K7/10C08J7/04B33Y70/10A01K27/00
Inventor 周武艺付荣杰聂健良刘子博徐远扬陈朝立
Owner SOUTH CHINA AGRI UNIV
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