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Fingerprint spectrum detection method for Shalian stomach-harmonizing capsule

A fingerprint and capsule technology, applied in the field of quality inspection of traditional Chinese medicine, can solve problems such as complex components, and achieve the effects of good stability, good system adaptability and strong specificity

Pending Publication Date: 2021-10-29
数源汇通(北京)医药科技有限公司
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  • Abstract
  • Description
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Problems solved by technology

However, the Chinese patent medicines of Sha Lian He Wei Capsules have various raw materials and complex components. Only the qualitative identification of the index components by thin-layer chromatography and the quantitative determination of a single index component by high-performance liquid chromatography are not enough to fully reflect the quality of Sha Lian He Wei capsules. The quality of stomach capsules

Method used

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  • Fingerprint spectrum detection method for Shalian stomach-harmonizing capsule
  • Fingerprint spectrum detection method for Shalian stomach-harmonizing capsule
  • Fingerprint spectrum detection method for Shalian stomach-harmonizing capsule

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Embodiment 1

[0069] Investigation of extraction methods: The extraction solvents investigated include methanol, 70% methanol, 50% methanol, 95% ethanol, 70% ethanol, 50% ethanol, pure water, petroleum ether, n-butanol. The experimental results show that the polarity of petroleum ether and n-butanol is too small to extract the target compound, while methanol has a better extraction effect than ethanol, and pure methanol has a better extraction effect on different batches of Salian and Wei capsules. Good extraction effect, strong applicability.

[0070] The extraction methods investigated included ultrasonic extraction, reflux extraction, and the above extraction methods with different standing times. It was found that the extraction efficiency of reflux and ultrasonic was similar, but the operation of reflux was more complicated, and the content did not change significantly after standing treatment. The solid-liquid ratio (the amount ratio of the extraction solvent (ml) added per g capsule ...

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Abstract

The invention discloses a fingerprint spectrum construction and detection method for a Shalian stomach-harmonizing capsule. Octadecylsilane chemically bonded silica is used as a filler, a phosphate aqueous solution is used as a mobile phase A, acetonitrile is used as a mobile phase B, and gradient elution is carried out to obtain the fingerprint spectrum with 17 common peaks. The method is easy to operate and high in stability and repeatability, the obtained fingerprint spectrum is rich in spectrum information, and the method can be used for comprehensively evaluating and controlling the quality of theShalian stomach-harmonizing capsule.

Description

technical field [0001] The invention relates to the technical field of quality detection of traditional Chinese medicines, in particular to a construction method and a detection method of the fingerprints of Shalian and Wei capsules. Background technique [0002] Sha Lian He Wei Capsule comes from the proven prescription of the Miao nationality. It is composed of Osmunda guanzhong (stir-fried with bran), Coptis chinensis (roasted with wine), Amomum kernel, Adenophora pilosulae, dried tangerine peel and Tumuxiang six herbs. Osmunda officinalis clears heat and detoxifies, removes blood stasis and stops bleeding; Coptis chinensis clears away heat and dampness, purifies fire and detoxifies; Ginseng nourishes yin and clears lungs, nourishes stomach and promotes body fluid; Resolving phlegm; Tumuxiang strengthens the spleen and harmonizes the stomach, regulates qi and relieves depression, and the combination of various medicines has the effects of clearing away heat and nourishing...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/86
CPCG01N30/02G01N30/8686G01N30/8679
Inventor 于泳向前孙毅坤吴昊
Owner 数源汇通(北京)医药科技有限公司
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