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Vascular graft and methods for sealing a vascular graft

A technology for artificial blood vessels and sealants, applied in the field of medical devices, which can solve the problems of changing time, complex time-consuming, long regulatory approval process, etc.

Pending Publication Date: 2021-10-26
TC1 LLC ST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, regulatory requirements for such animal products can be dynamic and may change over time and across countries
In addition, some countries do not allow any products of animal origin for human administration
In addition, products that include products of animal origin have potentially more complex and time-consuming regulatory approval processes than those that do not, due to additional regulatory requirements

Method used

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  • Vascular graft and methods for sealing a vascular graft
  • Vascular graft and methods for sealing a vascular graft
  • Vascular graft and methods for sealing a vascular graft

Examples

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example 1

[0045] In Example 1, an albumin-based hydrogel sealant was prepared and applied to a specific graft material, and the final water permeability of the hydrogel-sealed graft material was determined.

[0046]A 30% solution of recombinant human serum albumin (rHSA) was dissolved in a carbonate-bicarbonate solution at pH 9.6 (pH 9.6), and the bifunctional activated ester SS-PEO-SS (succinimide succinic acid Ester-polyethylene oxide-succinimidyl succinate) (molecular weight ~3,400 g / mol) was dissolved in phosphate buffer solution at pH 7.4 at a ratio of 0.130 g SS-PEO-SS per mL of albumin solution. The two solutions were filled into two separate syringes, and the graft (8 mm to 22 mm) was stretched over the mandrel and mounted on the motor. The two solutions were sprayed onto the graft while the graft was rotating axially at approximately 600 rpm. The reaction between rHSA and PEO occurs within seconds to form a hydrogel sealant ( image 3 ). Such as image 3 As shown, hydrogel ...

example 2

[0049] In Example 2, 4-ARM PEG (4-arm polyethylene glycol) with a lysine-lysine-lysine based hydrogel sealant was prepared and applied to a specific graft material and Determination of the ultimate water permeability of the hydrogel seal graft material.

[0050] Dissolve 4-ARM-PEO-SG (4-arm-polyethylene glycol-succinimide glutarate) (0.675 g; 6.2 micromole) in 4 ml of PBS (pH 7.4) and lysine Acid-lysine (0.025 g; 6.2 micromol) was dissolved in 4 ml of carbonate-bicarbonate buffer (pH 9.6). Fill the two solutions separately into dual syringe barrels. A 14 mm low porosity graft was stretched over a mandrel and the mandrel was attached to the motor. The graft is rotated axially at approximately 600 rpm. The solution was mixed and sprayed onto the rotating graft under nitrogen pressure to form a uniform coating on the graft. The hydrogel was allowed to form over a period of about 15 minutes. Water was removed from the hydrogel and stabilized by dehydrating the hydrogel in a m...

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Abstract

Disclosed herein is a vascular graft and a method for sealing a vascular graft. The method generally includes applying a hydrogel sealant to the vascular graft thereby sealing the graft, wherein the hydrogel sealant is prepared from material selected from the group consisting of plant sourced material, synthetic material, or a combination thereof. In some embodiments, the hydrogel sealant may be prepared from albumin and a crosslinking agent or from poly(ethylene)oxide and a poly(amine).

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application Serial No. 62 / 807,498, filed February 19, 2019, the entire disclosure of which is incorporated herein by reference. technical field [0003] The present invention relates generally to medical devices for use in the human body. In particular, the present invention relates to various artificial blood vessels and methods of sealing artificial blood vessels using flexible and biocompatible hydrogel sealants. Background technique [0004] Vascular grafts are often used in combination with medical devices such as ventricular assist devices. Many artificial blood vessels are constructed of large diameter knitted or braided polyester materials that perform well in the human body. In some cases, these large-diameter knitted or braided polyester materials may leak blood within a short time after introduction due to the high porosity of the graft material....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/18A61L27/34A61L27/50A61L27/52
CPCA61L27/507A61L27/52A61L27/34A61L27/16A61L27/18A61M60/216A61M60/857A61M60/178A61M60/117C08L89/00C08L27/18C08L67/02C08L67/04C08L75/04A61L24/0031A61L24/043
Inventor R·B·贾亚拉曼
Owner TC1 LLC ST
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