A kind of production process of anhydrous calcium hydrogen phosphate of medicinal adjuvant with direct pressure function

A technology of anhydrous calcium hydrogen phosphate and pharmaceutical excipients, applied in inorganic chemistry, phosphorus compounds, chemical instruments and methods, etc., can solve problems such as insufficient fluidity, achieve good overall fluidity, and help direct compression, pelletizing, etc. The effect of small diameter difference

Active Publication Date: 2022-07-19
HUZHOU ZHANWANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, in the preparation method of this invention patent, the steps are still to first obtain hydrous calcium hydrogen phosphate crystals, and then remove the water of crystallization, so that the finally obtained anhydrous calcium hydrogen phosphate particles are still mostly irregular in shape, such anhydrous phosphoric acid Calcium hydrogen granules cannot be directly compressed, and their fluidity is not enough

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A production process for a medicinal adjuvant anhydrous calcium hydrogen phosphate with a direct pressure function, comprising the following steps in turn:

[0048] S1, prepare calcium hydroxide slurry;

[0049] S2, prepare dilute phosphoric acid;

[0050] S3, described calcium hydroxide slurry and dilute phosphoric acid neutralization reaction, obtain suspension;

[0051] S4, carrying out solid-liquid separation to the suspension, and dispersing and beating the solid with distilled water or deionized water to obtain a slurry;

[0052] S5, spray drying and sieving the slurry to obtain the final anhydrous calcium hydrogen phosphate product.

[0053] In S1, the solid content of the calcium hydroxide slurry is 20%, and distilled water is used for preparation.

[0054] In S2, the mass fraction of the dilute phosphoric acid is 22%, and the concentrated phosphoric acid with a mass fraction of 85% and distilled water are used for preparation.

[0055] In S3, the specific o...

Embodiment 2

[0067] A production process for a medicinal adjuvant anhydrous calcium hydrogen phosphate with a direct pressure function, comprising the following steps in turn:

[0068] S1, prepare calcium hydroxide slurry;

[0069] S2, prepare dilute phosphoric acid;

[0070] S3, described calcium hydroxide slurry and dilute phosphoric acid neutralization reaction, obtain suspension;

[0071] S4, carrying out solid-liquid separation to the suspension, and dispersing and beating the solid with distilled water or deionized water to obtain a slurry;

[0072] S5, spray drying and sieving the slurry to obtain the final anhydrous calcium hydrogen phosphate product.

[0073] In S1, the solid content of the calcium hydroxide slurry is 26%, and distilled water is used for preparation.

[0074] In S2, the mass fraction of the dilute phosphoric acid is 29%, and the concentrated phosphoric acid with a mass fraction of 85% and distilled water are used for preparation.

[0075] In S3, the specific o...

Embodiment 3

[0087] A production process for a medicinal adjuvant anhydrous calcium hydrogen phosphate with a direct pressure function, comprising the following steps in turn:

[0088] S1, prepare calcium hydroxide slurry;

[0089] S2, prepare dilute phosphoric acid;

[0090] S3, described calcium hydroxide slurry and dilute phosphoric acid neutralization reaction, obtain suspension;

[0091] S4, carrying out solid-liquid separation to the suspension, and dispersing and beating the solid with distilled water or deionized water to obtain a slurry;

[0092] S5, spray drying and sieving the slurry to obtain the final anhydrous calcium hydrogen phosphate product.

[0093] In S1, the solid content of the calcium hydroxide slurry is 24%, and distilled water is used for preparation.

[0094] In S2, the mass fraction of the dilute phosphoric acid is 30%, and the concentrated phosphoric acid with a mass fraction of 90% and distilled water are used for preparation.

[0095] In S3, the specific o...

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Abstract

The invention belongs to the technical field of the synthesis of pharmaceutical excipients, in particular to a production process of anhydrous calcium hydrogen phosphate for pharmaceutical excipients with a direct pressure function. In the present invention, spherical anhydrous calcium hydrogen phosphate is finally obtained through the five-step operations of preparing calcium hydroxide slurry, preparing dilute phosphoric acid, neutralization reaction, solid-liquid separation and beating, and spray drying and screening. Fluidity to meet the technological requirements of direct compression tablets. The invention has the following advantages: in the production process of anhydrous calcium hydrogen phosphate, a crystallization inhibitor is used, and a rapid cooling operation is used to directly obtain anhydrous calcium hydrogen phosphate crystals, instead of first obtaining water-containing calcium hydrogen phosphate crystals and then removing crystal water, Combined with the spray drying process, the final anhydrous calcium hydrogen phosphate product has a suitable particle size and a regular spherical shape, which meets the requirements of direct compression tablets.

Description

technical field [0001] The invention belongs to the technical field of synthesizing pharmaceutical excipients, in particular to a production process of anhydrous calcium hydrogen phosphate for pharmaceutical excipients with a direct pressure function. Background technique [0002] Powder Direct Compression (PDC) refers to the process of directly compressing the powder of the API and suitable excipients after sieving and mixing, without going through the step of granulation. Compared with the traditional first granulation and then tableting process, PDC has the advantages of good product stability, high production efficiency, good reproducibility, energy saving, time saving and cost saving. [0003] When anhydrous calcium hydrogen phosphate is used for powder direct pressing operation, it is required to have relatively high fluidity and compressibility. The specific performance is that at least the particle shape of anhydrous calcium hydrogen phosphate is required to be regul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32
CPCC01B25/322C01P2004/32C01P2004/03
Inventor 潘继成金晓民杨建荣臧月龙沈佳张楠沈志佳
Owner HUZHOU ZHANWANG PHARMA
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