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Rhizoma bergeniae scopulosae traditional Chinese medicine composition tincture for treating osteoarthritis and preparation method thereof

An osteoarthritis and composition technology, applied in the field of traditional Chinese medicine compositions and traditional Chinese medicine preparations, can solve the problems of low bioavailability and small drug loading, and achieve high drug content, sufficient drug loading and good permeability. Effect

Inactive Publication Date: 2021-10-26
SHAANXI PANLONG PHARMACEUTICAL GROUP LIMITED BY SHARE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] As an ordinary sugar-coated tablet, Panlongqi Tablets has a small drug load, and due to the first-pass effect of the drug after oral administration, the bioavailability is very low

Method used

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  • Rhizoma bergeniae scopulosae traditional Chinese medicine composition tincture for treating osteoarthritis and preparation method thereof
  • Rhizoma bergeniae scopulosae traditional Chinese medicine composition tincture for treating osteoarthritis and preparation method thereof
  • Rhizoma bergeniae scopulosae traditional Chinese medicine composition tincture for treating osteoarthritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] According to the drug combination, weigh Panlongqi 10g, Gentiana 10g, Achyranthes bidentata 5g, Salvia miltiorrhiza 20g, Acanthopanax 10g, Valerian 5g, Balima 5g, Guoshanlong 5g Bawei medicinal materials, pulverize, and pass through a 20-mesh sieve. , add 1200mL of 70% ethanol, reflux and stir for extraction 3 times, each extraction for 1 hour, filter, cool naturally, let stand for 24h, filter, and combine the filtrates to obtain 1118mL extract 1, which is set aside. According to the drug combination, weigh Angelica 30g, Chonglou 20g, Frog Seven 1g, Chuanwu 1g, Grass Aconitum 1g, Iron Cudgel Hammer 1g, Pearl Ginseng 1g, Pterocarpus vine 5g, Cinnamomum chinensis 5g, Woody Fragrance 5g, Frankincense 5g, Zusima 1g, Baimaoqi 1g, Mouseqi 1g, Eucommia 10g, Safflower 5g, Zhuangjindan 1g, Myrrh 5g, Shenjincao 1g, Pillar Polygonum 5g and Bamboo Root Seven 5g, a total of 21 Flavor medicinal materials, add 1800mL 50% ethanol, reflux and stir to extract 3 times, extract for 1 hour ...

Embodiment 2

[0026] According to the drug combination, weigh Panlongqi 16.7g, Gentiana 16.7g, Achyranthes bidentata 8.3g, Salvia miltiorrhiza 25g, Wujiapi 16.7g, valerian 8.3g, Balima 8.3g, and Guoshanlong 8.3g. , crushed, passed through a 20-mesh sieve, added 1200mL of 70% ethanol, refluxed and stirred for extraction 3 times, each extraction was 1 hour, filtered, cooled naturally, left to stand for 24h, filtered, and the combined filtrates were obtained to obtain 1124mL extract 1, which was set aside. According to the drug combination, weigh 41.7g of Angelica sinensis, 25g of Chonglou, 1.7g of Frog Seven, 1.7g of Chuanwu, 1.7g of Aconitum, 1.7g of Iron Rod Hammer, 1.7g of Pearl Ginseng, 8.3g of Catenia, 8.3g, woody 8.3g, frankincense 8.3g, zusima 8.3g, white hair seven 1.7g, mouse seven 1.7g, Eucommia 16.7g, safflower 8.3g, strong gluten pill 3.3g, myrrh 8.3g, Add 3.3g of tendon grass, 8.3g of Polygonum striatum and 8.3g of bamboo root seven, a total of 21 medicinal materials, add 1800mL ...

Embodiment 3

[0028] According to the drug combination, weigh Panlongqi 20g, Gentiana chinensis 20g, Achyranthes bidentata 10g, Salvia miltiorrhiza 30g, Wujiapi 20g, Valerian root 10g, Balima 10g, Guoshanlong 10g Bawei medicinal materials, pulverize, and pass through a 20-mesh sieve. , add 1200mL of 70% ethanol, reflux and stir to extract 3 times, extract for 1 hour each time, filter, cool naturally, let stand for 24h, filter, and combine the filtrates to obtain 1128mL extract 1, which is set aside. According to the drug combination, weigh Angelica 50g, Chonglou 30g, Frog Seven 3g, Chuanwu 3g, Grass Aconitum 3g, Iron Crow Hammer 3g, Pearl Ginseng 3g, Trichophyllum 10g, Cinnamomum chinensis 10g, Muxiang 10g, frankincense 10g, Zusima 3g, Baimaoqi 5g, Mouseqi 5g, Eucommia 20g, Safflower 10g, Zhuangjindan 5g, Myrrha 10g, Shenjincao 5g, Pillar Polygonum 10g and Bamboo Root Seven 10g, a total of 21 Flavor medicinal materials, add 1800mL 50% ethanol, reflux and stir to extract 3 times, extract for...

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Abstract

The invention provides a rhizoma bergeniae scopulosae traditional Chinese medicine composition tincture for treating osteoarthritis and a preparation method thereof. The rhizoma bergeniae scopulosae traditional Chinese medicine composition tincture is obtained by extracting compositions through ethanol. The rhizoma bergeniae scopulosae traditional Chinese medicine composition tincture comprises the following compositions in parts by weight: 10-20 parts of rhizoma bergeniae scopulosae, 10-20 parts of large-leaved gentian, 5-10 parts of radix achyranthis bidentatae, 20-30 parts of radix salviae miltiorrhizae, 10-20 parts of cortex acanthopanacis, 5-10 parts of valerian, 5-10 parts of Chinese azalea fruits, 5-10 parts of vernonia gratiosa, 30-50 parts of radix angelicae sinensis, 20-30 parts of rhizoma paridis, 1-3 parts of iris tectorum, 1-3 parts of radix aconiti, 1-3 parts of radix aconiti agrestis, 1-3 parts of aconitum flavum, 1-3 parts of rhizoma panacis majoris, 5-10 parts of caulis trachelospermi, 5-10 parts of bletilla, 5-10 parts of radix aucklandiae, 5-10 parts of olibanum, 1-3 parts of cortex daphnes, 1-5 parts of chloranthus japonicus, 1-5 parts of hylomecon japonica, 10-20 parts of cortex eucommiae, 5-10 parts of flos carthami, 1-5 parts of sinew-strengthening pills, 5-10 parts of myrrh, 1-5 parts of herba lycopodii, 5-10 parts of herba polygoni capitati and 5-10 parts of rhizoma tupistrae chinensis. The rhizoma bergeniae scopulosae composition tincture is large in drug loading capacity, can directly act on an affected part, and increases the bioavailability of the drug through transdermal absorption.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine compositions and traditional Chinese medicine preparations, in particular to a panlongqi traditional Chinese medicine tincture for treating osteoarthritis and a preparation method thereof. Background technique [0002] When the meridians on the surface of the human body are attacked by wind, cold, and dampness, the flow of Qi and blood is not smooth, causing pain, numbness, swelling, stretching and flexion of the bones, muscles, and joints, and migratory redness, swelling, and pain in the joints of the whole body. , all belong to "arthritis". Treatment is mainly based on expelling wind and dredging collaterals, accompanied by expelling cold and dampness. It has been found clinically that Panlong Seven Tablets can unblock the organs, unblock Qi and blood, and achieve the effects of promoting blood circulation and removing blood stasis, reducing swelling and pain, dredging meri...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K36/898A61K9/08A61K47/10A61P19/02A61P29/00
CPCA61K36/185A61K36/896A61K36/714A61K36/898A61K36/51A61K36/21A61K36/537A61K36/254A61K36/84A61K36/28A61K36/87A61K36/232A61K36/88A61K36/25A61K36/344A61K36/24A61K36/285A61K36/324A61K36/83A61K36/66A61K36/46A61K36/286A61K36/36A61K36/328A61K36/12A61K36/704A61K9/0014A61K9/08A61K47/10A61P19/02A61P29/00A61K2236/333A61K2236/39A61K2236/53A61K2236/51A61K2300/00
Inventor 谢晓林张德柱梁承远丁顺军刘玉枝马钊周绪华孟重孟建国
Owner SHAANXI PANLONG PHARMACEUTICAL GROUP LIMITED BY SHARE LTD
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