Water-in-oil scar repair microemulsion and preparation method thereof

A water-in-oil type and microemulsion technology, which is applied in the fields of emulsion delivery, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of limited application and poor water solubility of Centella asiatica, and achieve simple process, wide application range, and improved The effect of repairing scars

Active Publication Date: 2021-10-26
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is: the poor water solubility of Centella asiatica leads to the problem that its application in cosmetics is limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A water-in-oil type scar repair microemulsion, the oil phase includes an emulsifier and vegetable oil active ingredients, and the water phase includes Centella asiatica extract and a solvent, wherein polyglyceryl ricinoleate is used as the emulsifier, and lavender essential oil is used as the vegetable oil Active ingredient, polyethylene glycol-400 and 1,3-propanediol as solvents.

[0036] The preparation method of the above-mentioned water-in-oil type scar repair microemulsion specifically comprises the following steps:

[0037] (1) At room temperature, mix the vegetable oil active ingredient and emulsifier in a certain proportion, stir evenly, fully mix the oil phase and emulsifier, transfer it to a container, place it on a constant temperature oscillator, and keep shaking for 12 hours. At 25°C, phase A was obtained;

[0038] Wherein, the consumption of vegetable oil active ingredient and emulsifier is calculated according to the ratio of 5:1 by mass ratio, and the c...

Embodiment 2

[0044] A water-in-oil type scar repair microemulsion, the oil phase includes an emulsifier and vegetable oil active ingredients, and the water phase includes Centella asiatica extract and a solvent, wherein Span-80 is used as an emulsifier, lavender essential oil and patchouli oil are used It is the active ingredient of vegetable oil, with 1,3-butanediol as the solvent.

[0045] The preparation method of the above-mentioned water-in-oil type scar repair microemulsion specifically comprises the following steps:

[0046] (1) At room temperature, mix the vegetable oil active ingredient and emulsifier in a certain proportion, stir evenly, fully mix the vegetable oil active ingredient phase and emulsifier, transfer it to a container, place it on a constant temperature oscillator, and continue shaking for 12 hours , at a temperature of 25°C, to obtain phase A;

[0047] Wherein, the consumption of vegetable oil active ingredient and emulsifier is calculated according to the ratio of...

Embodiment 3

[0052] A water-in-oil microemulsion for scar repair, the oil phase includes an emulsifier and vegetable oil active ingredients, and the water phase includes Centella asiatica extract and a solvent, wherein polyglyceryl ricinoleate is used as an emulsifier, lavender essential oil and Patchouli oil is an active ingredient of vegetable oil, and polyethylene glycol-400 and 1,3-propanediol are used as solvents.

[0053] The preparation method of the above-mentioned water-in-oil type scar repair microemulsion specifically comprises the following steps:

[0054] (1) At room temperature, mix the vegetable oil active ingredient and emulsifier in a certain proportion, stir evenly, transfer the vegetable oil active ingredient and emulsifier to a container, place it on a constant temperature shaker, and keep shaking for 12 hours. The temperature is 25°C to obtain phase A;

[0055] Wherein, the consumption of vegetable oil active ingredient and emulsifier is calculated according to the ra...

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PUM

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Abstract

The invention discloses a water-in-oil scar repair microemulsion and a preparation method thereof. The scar repair microemulsion comprises an emulsifier, a solvent, a centella asiatica extract and plant oil active ingredients. The preparation method comprises the following steps of uniformly mixing the plant oil active ingredients and the emulsifier at room temperature to obtain an oil phase, dissolving the centella asiatica extract in the solvent to obtain a water phase, and adding the water phase into the oil phase under a stirring condition to obtain the water-in-oil scar repair microemulsion. The scar repair microemulsion prepared by the invention has triple skin care effects of removing scar tissues, nourishing skin and fading pigments, and overcomes the defects of poor solubility and small application range of the centella asiatica extract. The microemulsion prepared by the invention is a water-in-oil system, has relatively high stability, can be independently used, can also be added into oil type cosmetics, and is convenient to use, simple in process and easy to produce.

Description

technical field [0001] The invention relates to a water-in-oil type scar repair microemulsion and a preparation method thereof, belonging to the technical field of cosmetics and medicine. Background technique [0002] Scar is the fibrous tissue that replaces normal skin after human skin injury. It is a general term for the appearance, morphology and histopathological changes of normal skin tissue, and it is also the inevitable result of wound healing. Scars not only destroy the beauty of the body surface, but may also affect the function of related tissues or organs, and even cause deformities in more serious cases. As people pay more attention to their own appearance, skin wound repair has become a hot spot in the cosmetics industry and plastic surgery industry. [0003] The main components of lavender essential oil are linalool, camphor, linalyl acetate, lavender alcohol, eucalyptol and other compounds. It has a certain protective effect on wound healing. Studies have co...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/34A61K8/86A61K8/92A61K8/06A61K36/532A61K9/107A61Q19/00A61P17/02A61P17/00
CPCA61K8/9789A61K8/068A61K8/922A61K8/345A61K8/86A61Q19/00A61Q19/005A61P17/02A61K8/064A61K36/532A61K36/23A61K9/1075A61K36/53A61P17/00A61K2800/262A61K2800/21A61K2800/5922A61K2300/00
Inventor 宋晓秋郭鑫叶琳
Owner SHANGHAI INST OF TECH
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