Preparation method of aminophenol containing methylene
A technology of aminophenol and methylene, applied in the field of aminophenol preparation, can solve the problems that the yield of aminophenol is difficult to exceed 65%, and the risk is high
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Embodiment 1
[0051] Embodiment 1: the preparation of 4-((4-aminophenyl)-methylene)phenol
[0052] 4-((4-aminophenyl)-methylene)phenol, the specific structural formula is shown in formula (4).
[0053]
[0054] The synthetic process of 4-((4-aminophenyl)-methylene)phenol shown in formula (4) is shown in the following formula:
[0055]
[0056] Specifically, the preparation method of 4-((4-aminophenyl)-methylene)phenol shown in formula (4) comprises the following steps:
[0057] Under a nitrogen gas atmosphere, mix aniline hydrochloride (26.0g, 0.2mol), p-hydroxymethylphenol (12.4g, 0.1mol), and aniline (24mL, 0.2mol) in a three-necked flask, heat the reaction, and heat the temperature of the reaction The temperature is 120°C, the heating reaction time is 1.5 hours, the mixture obtained after the heating reaction is poured into water, and NaHCO is added 3After neutralization to neutrality, add ethyl acetate for extraction and separation. After the organic layer is dried and the solve...
Embodiment 2
[0062] Compared with Example 1, the difference of Example 2 is only that the temperature of the heating reaction in Example 2 is 130° C., and the reaction time is 1 hour, and the obtained 4-((4-aminophenyl)-methylene ) The yield of phenol was 81.0%.
Embodiment 3
[0064] Compared with Example 1, the only difference in Example 3 is that the amount of aniline in Example 3 is 0.15mol, and the yield of 4-((4-aminophenyl)-methylene)phenol is 79.1 %.
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