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Method for obtaining liver phosphorus spectrum based on 31P-MRS and liver ATP metabolism index

A 31P-MRS and liver technology, applied in diagnostic recording/measurement, medical science, diagnosis, etc., can solve the problems of signal pollution, long scanning time, etc., achieve high accuracy, avoid spectral overlap and low signal-to-noise ratio

Pending Publication Date: 2021-10-22
HARBIN MEDICAL UNIVERSITY
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Problems solved by technology

ISIS requires long scan times, is very sensitive to motion, and is susceptible to signal contamination by substances outside the region of interest (VOI)

Method used

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  • Method for obtaining liver phosphorus spectrum based on 31P-MRS and liver ATP metabolism index
  • Method for obtaining liver phosphorus spectrum based on 31P-MRS and liver ATP metabolism index
  • Method for obtaining liver phosphorus spectrum based on 31P-MRS and liver ATP metabolism index

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Embodiment Construction

[0030] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0031] a based on 31 The method for obtaining liver phosphorus spectrum by P-MRS comprises the following steps:

[0032] (1) Establish model animals;

[0033]1) 6-week-old male Sprague-Dawley rats were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. and raised in the animal room of the Molecular Imaging Research Center of Harbin Medical University. Feed sterile rat chow and clean water, and keep in the ...

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Abstract

The invention provides a method for obtaining liver phosphorus spectrum based on 31P-MRS and a liver ATP metabolism index, the parameters of a phosphorus spectrum scanning sequence are optimized through a method for reasonably fixing and placing the positions of an animal and a coil, the phosphorus spectrum with the high SNR is obtained on a 9.4 T high-field-intensity small animal magnetic resonance imaging system, separation of multiple characteristic metabolite peaks is achieved, the specific values of beta-ATP / Pt and beta-ATP / Pi, namely beta-ATP, relative to total phosphorus metabolites (Pt) and Pi are determined, the ATP metabolism change condition in the liver fibrosis development process can be accurately monitored through the change of the specific values, and the correlation between phosphorus spectrum change and energy metabolism change is verified; the index is expected to be used as a clinical index to realize non-invasive and repeatable examination of hepatic fibrosis in combination with other examinations, so that early and accurate diagnosis of hepatic fibrosis is realized.

Description

technical field [0001] The invention relates to the technical field of characteristic phosphorus spectrum screening, in particular to a method based on 31 The method of P-MRS to obtain liver phosphorus spectrum and the index of liver ATP metabolism. Background technique [0002] Liver disease is a common and frequently-occurring disease in my country at present. Liver fibrosis is the intermediate link of many liver diseases. Gradually aggravated liver fibrosis will lead to irreversible liver cirrhosis, and even lead to liver cancer if not controlled in time. Therefore, early diagnosis and prevention of liver fibrosis is the key to prevent the further development of liver disease. The diagnosis of liver diseases is still based on the pathological criteria of liver biopsy. Biopsy is the gold standard for the diagnosis of liver diseases. However, it is an invasive examination, and the tissue obtained by biopsy is limited, so it is not suitable for screening and monitoring the...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055
CPCA61B5/055A61B5/0033A61B5/004
Inventor 孙夕林刘阳郑利敏王凯李昊翔杨洁孙晓红乔文菊
Owner HARBIN MEDICAL UNIVERSITY
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