Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for determining total chlorine content in compound preparation containing sodium citrate

A determination method and compound preparation technology, applied in the field of medicine, can solve problems such as interference in the determination of total chlorine content, influence on the judgment of the titration end point, etc., and achieve the effect of ensuring accuracy

Inactive Publication Date: 2021-10-19
西安乐析医疗科技有限公司
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the prescription of balanced salt solution (for perfusion) contains sodium citrate, and sodium citrate and silver nitrate can undergo redox reactions to generate water-insoluble nano-silver, which will interfere with the determination of total chlorine content and affect the titration end point. judge

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for determining total chlorine content in compound preparation containing sodium citrate
  • Method for determining total chlorine content in compound preparation containing sodium citrate
  • Method for determining total chlorine content in compound preparation containing sodium citrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0026] see figure 1 and figure 2 , the present invention provides a kind of technical scheme: a kind of assay method containing total chlorine content in sodium citrate compound preparation, assay method is as follows:

[0027] Step 1: Accurately measure 10ml of this product, add 1ml of 0.1mol / L calcium nitrate solution, and add 0.1ml of dilute nitric acid;

[0028] Step 2: Add 5ml of 2% dextrin solution and 8 drops of dichlorofluorescent yellow indicator s...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
recovery rateaaaaaaaaaa
Login to View More

Abstract

The invention discloses a method for measuring the total chlorine content in a compound preparation containing sodium citrate, which comprises the following steps: 1, precisely measuring 10ml of the compound preparation, adding 0-3ml of 0.1 mol / L calcium nitrate solution, and adding 0-0.3 ml of dilute nitric acid; 2, adding 5ml of 2% dextrin solution and 8 drops of dichlorofluorescein indicating liquid; 3, titrating with a silver nitrate titration solution (0.1 mol / L); as a preferable technical scheme of the invention, each 1ml of silver nitrate titration solution (0.1 mol / L) is equivalent to 3.545 mg of chlorine; the method has the beneficial effects that 10 ml of the compound preparation is precisely measured, 5 ml of a 2% dextrin solution and 8 drops of the dichlorofluorescein indicator solution are added, titration is performed by using the silver nitrate titration solution (0.1 mol / L), and on the basis that 1 ml of the silver nitrate titration solution (0.1 mol / L) is equivalent to 3.545 mg of chlorine], 1 ml of the 0.1 mol / L calcium nitrate solution and 0.1 ml of dilute nitric acid are added, so that the influence of sodium citrate in the compound preparation containing sodium citrate on the total chlorine content determination can be eliminated, therefore, the accuracy of total chlorine content determination is ensured.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for determining the total chlorine content in a compound preparation containing sodium citrate. Background technique [0002] Balanced salt solution (for perfusion) is a typical compound preparation containing sodium citrate, specifically composed of 0.64% sodium chloride, 0.075% potassium chloride, 0.048% calcium chloride dihydrate, 0.03% magnesium chloride hexahydrate, Sodium acetate trihydrate 0.39%, sodium citrate dihydrate 0.17% is a colorless and clear liquid; it is mainly used in ophthalmic surgery for intraocular or extraocular perfusion fluid and endoscopic surgery flushing fluid and various It is a kind of irrigating solution for the bone and joint cavity, and it can also be used for various surgical flushing, lavage, and cleaning that allow the use of electrolyte solutions, such as various body cavities, tissues, wounds, and drainage tubes that re...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N31/16
CPCG01N31/16
Inventor 张鑫李继仁田景云耿会力赵萍萍
Owner 西安乐析医疗科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com