Cytisine tablet and preparation method thereof

A technology of cytisine tablets and cytisine, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., can solve the problem of low bioavailability, and achieve tablet The effect of controllable quality and simple process

Pending Publication Date: 2021-09-28
BEIJING VENTUREPHARM BIOTECH
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to overcome the shortcomings of cytisine and low bioavailability, the inventors of the present invention provided a c

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cytisine tablet and preparation method thereof
  • Cytisine tablet and preparation method thereof
  • Cytisine tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0006] A kind of cytisine tablet, is made of the component that comprises following percentage by weight:

[0007]

[0008] (1) Pretreatment of raw and auxiliary materials: crush the raw material cytisine through a 200-mesh sieve; the particle size of the raw material is 20 μm;

[0009] (2) Mixing: Mix cytisine and filler disintegrant for 10 to 30 minutes to make them uniform;

[0010] (3) Add the prescribed amount of magnesium stearate to the powder mixed uniformly in step (2), and mix for 3 to 5 minutes to make it uniform;

[0011] (4) Directly compress the uniformly mixed drug powder in step (3), and control the hardness within the range of 50N to 80N.

Embodiment 2

[0013] A kind of cytisine tablet, is made of the component that comprises following percentage by weight:

[0014]

[0015] (1) Pretreatment of raw and auxiliary materials: crush the raw material cytisine and pass through a 200-mesh sieve; the particle size of the raw material is 26 μm;

[0016] (2) Mixing: Mix cytisine and filler disintegrant for 10 to 30 minutes to make them uniform;

[0017] (3) Add the prescribed amount of magnesium stearate to the powder mixed uniformly in step (2), and mix for 3 to 5 minutes to make it uniform;

[0018] (4) Directly compress the uniformly mixed drug powder in step (3), and control the hardness within the range of 50N to 80N.

Embodiment 3

[0020] A kind of cytisine tablet, is made of the component that comprises following percentage by weight:

[0021]

[0022] (1) Pretreatment of raw and auxiliary materials: crush the raw material cytisine through a 200-mesh sieve; the particle size of the raw material is 20 μm;

[0023] (2) Mixing: Mix cytisine and filler disintegrant for 10 to 30 minutes to make them uniform;

[0024] (3) Add the prescribed amount of magnesium stearate to the powder mixed uniformly in step (2), and mix for 3 to 5 minutes to make it uniform;

[0025] (4) Directly compress the uniformly mixed drug powder in step (3), and control the hardness within the range of 50N to 80N.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Sheet weightaaaaaaaaaa
Hardnessaaaaaaaaaa
Login to view more

Abstract

The invention relates to the technical field of medicines, in particular to a novel cytisine tablet and a preparation method thereof. The novel cytisine tablet is characterized by comprising cytisine, in addition to a filling agent, a disintegrating agent, a lubricating agent and a flavoring agent. The invention further discloses the preparation method, According to the preparation method, and direct compression of powder is adopted, the technical process is stable, mature, simple and suitable for large-scale production. The cytisine tablet provided by the invention has the advantages of rapid disintegration and the like. The quality of the prepared cytisine tablet is controllable, and the stability of the product is ensured.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, relates to a cytisine tablet and a preparation method thereof, and is a novel smoking cessation medicine with remarkable curative effect. . Background technique [0002] Cytisine is a class of alkaloids with a tricyclic structure of α-pyridone, and is mostly distributed in legumes and Berberidaceae plants. Clinically, cytisine can be used for intramuscular or intravenous injection to rescue reflex apnea, shock and neonatal asphyxia caused by surgery and various traumas. Some recent studies have shown that this type of alkaloid also has various biological activities such as anti-arrhythmia and anti-infection. In recent years, cytisine, as a smoking cessation drug with obvious curative effect, has attracted the attention of the international medical community. Contents of the invention [0003] The object of the present invention is to provide a cytisine tablet with simple process, f...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/20A61K31/439A61K47/38A61P25/34
CPCA61K9/2054A61K31/439A61P25/34
Inventor 董玉娇王宇杰
Owner BEIJING VENTUREPHARM BIOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap