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Bitterness receptor agonist and application thereof in prevention and treatment of SARS-CoV-2 related infectious diseases

A bitter taste receptor, sars-cov-2 technology, used in the field of medicine

Pending Publication Date: 2021-09-24
SHANGHAI CITY PUDONG NEW AREA GONGLI HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several new drugs are reported to be in clinical trials for SARS-CoV-2 (28), but are still in the early stages of development

Method used

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  • Bitterness receptor agonist and application thereof in prevention and treatment of SARS-CoV-2 related infectious diseases
  • Bitterness receptor agonist and application thereof in prevention and treatment of SARS-CoV-2 related infectious diseases
  • Bitterness receptor agonist and application thereof in prevention and treatment of SARS-CoV-2 related infectious diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0135] Example 1: Data collection and analysis

[0136] Gene expression data were retrieved from the EBI database and the merged CEL files were preprocessed using a powerful multichip averaging (RMA) normalization method. The critical value of the standard deviation level was 0.25 to ensure the high quality of the data and capture significantly correlated transcriptome information.

[0137] The inventors collected and preprocessed 60,000 Affymetrix expression chips and 5,000 TCGA datasets. KEGG analysis was performed to enrich the most significantly associated signaling pathways. Biological pathway analysis was performed for the genes with the highest negative correlation with TAS2R10 expression. Pearson correlations between the TAS2R10 probe and other probes were calculated and p-values ​​are unmodified p-values. The q-value package in R is used for multiple testing correction. Genes with q-values ​​below 0.05 were considered as significantly negative co-expressed genes o...

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PUM

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Abstract

The invention relates to a bitter receptor agonist and application thereof in prevention and treatment of SARS-CoV-2 related infectious diseases. Specifically, the invention relates to application of a bitter receptor stimulant as a 2019 novel coronavirus (SARS-CoV-2) inhibitor in preparation of medicines for treating and / or preventing and relieving related diseases such as respiratory tract infection and pneumonia caused by 2019 novel coronavirus infection.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to a bitter receptor agonist and its application in the prevention and treatment of SARS-CoV-2 related infectious diseases. Background technique [0002] The disease caused by the novel coronavirus SARS-CoV-2 (also known as 2019-nCoV) causes systemic symptoms, is contagious, and has become a major outbreak worldwide (2-4). The coronavirus disease is officially named COVID-19 by the World Health Organization (WHO). International travel contributes to increased transmission (5). On January 30, 2020, WHO declared SARS-CoV-2 a Public Health Emergency of International Concern (PHEIC). On March 23, 2020, there had been more than 230,000 cases. The outbreak continues and is now considered a WHO-declared pandemic. The morbidity, mortality, and transmissibility of this novel coronavirus have not been resolved (6, 7). In the absence of effective antiviral treatment, mandatory measures mus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4453A61K31/4402A61K31/165A61K31/365A61K31/164A61K31/341A61K31/37A61K31/52A61K31/472A61K31/522A61K31/4745A61K31/4706A61K31/125A61K31/198A61K31/485A61K31/4515A61K31/49A61K31/475A61K31/575A61K31/192A61K31/426A61K31/45A61K31/7048A61K31/17A61K31/16A61K31/133A61K31/27A61K31/4741A61K31/166A61K31/155A61K31/10A61K31/196A61K31/085A61K31/573A61K31/357A61K45/06A61P31/14A61P11/00
CPCA61K31/4453A61K31/4402A61K31/165A61K31/365A61K31/164A61K31/341A61K31/37A61K31/52A61K31/472A61K31/522A61K31/4745A61K31/4706A61K31/125A61K31/198A61K31/485A61K31/4515A61K31/49A61K31/475A61K31/575A61K31/192A61K31/426A61K31/45A61K31/7048A61K31/17A61K31/16A61K31/133A61K31/27A61K31/4741A61K31/166A61K31/155A61K31/10A61K31/196A61K31/085A61K31/573A61K31/357A61K45/06A61P31/14A61P11/00
Inventor 李湘麒张朝宝任莉刘连勇顾明君
Owner SHANGHAI CITY PUDONG NEW AREA GONGLI HOSPITAL
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