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Application of American ginseng in forest mountain to preparation of medicine for treating antibiotic-associated diarrhea

An antibiotic, related technology, applied in the field of biomedicine

Pending Publication Date: 2021-09-14
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature report on the impact of WsAG on ADD

Method used

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  • Application of American ginseng in forest mountain to preparation of medicine for treating antibiotic-associated diarrhea
  • Application of American ginseng in forest mountain to preparation of medicine for treating antibiotic-associated diarrhea
  • Application of American ginseng in forest mountain to preparation of medicine for treating antibiotic-associated diarrhea

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 The preparation method of the American ginseng ethanol extract involved in the present invention is as follows:

[0024] Take fresh Panax ginseng samples from Linxia Mountain, dry and grind them, pass through a 40-mesh sieve, take 10g of the obtained powder and extract with 200ml 70% ethanol (v / v) under reflux, extraction temperature 80°C, 2h each time, extract 3 times, vacuum decompression Concentrate to obtain extract, and fully dry to obtain 2.75g of powder.

Embodiment 2

[0025] Embodiment 2: Preparation of Linxia Mountain American Ginseng Ethanol Extract Tablets involved in the present invention

[0026] Take 5g of American ginseng ethanol extract in the forest, add 30g of starch and mix evenly, spray 70% ethanol as a wetting agent to make a soft material; pass through a 20-mesh sieve to obtain wet granules, dry at 60°C, turn it every 30min, and control the water content at 1% to 3%. Add magnesium stearate powder, mix well, and press into 1000 tablets.

Embodiment 3

[0027] Embodiment 3: Preparation of Linxia Mountain American Ginseng Ethanol Extract Capsules involved in the present invention

[0028] Pass the raw and auxiliary materials through a No. 5 sieve to facilitate complete and uniform mixing. Weigh 5 g of Panax ginseng ethanol extract and 28 g of starch, mix evenly, and pack 1000 capsules.

[0029] The effects of the present invention will be further described below through experimental examples.

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Abstract

The invention relates to application of American ginseng in forest mountain in preparation of a medicine for treating antibiotic-associated diarrhea, and belongs to the field of biomedicine. Animal model experiments are carried out by adopting an ethanol extract of the American ginseng in the forest mountain. Experimental results prove that the ethanol extract of the American ginseng under the forest mountain has a relatively good protection effect on an antibiotic-related diarrhea experimental model caused by antibiotic drug combination, and has a reversal effect on pathological changes of colon and ileum of mice; expression of proinflammatory factors TNF-alpha, IL-1beta and IL-6 in serum of mice is inhibited, so that intestinal inflammation is relieved; the level of short-chain fatty acid in the intestinal tract of the mice can be recovered; the intestinal flora structure and diversity are improved; and pains of patients can be relieved, and life quality can be improved.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new medicinal material application of American ginseng from Linxia Mountain, in particular to the application of ethanol extract of American ginseng from Linxia Mountain in preparing medicine for treating antibiotic-associated diarrhea. Background technique [0002] Antibiotic-associated diarrhea (Antibiotic-associated diarrhea, AAD) is defined as diarrhea related to the use of antibiotics that cannot be explained by other reasons. It is a relatively common clinical complication of antibiotic use, with an incidence rate as high as 5% to 25%. ADD will not only hinder the recovery of the disease and aggravate the condition of critically ill patients, but also increase the mortality rate and bring a heavy burden to the family and society. [0003] There are different degrees of clinical symptoms of AAD: mild only manifests as diarrhea, without systemic symptoms, usually at least 3 times a ...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P1/12A61K125/00
CPCA61K36/258A61P1/12
Inventor 林红强余慧王彩霞李乐周柏松付书正刘云鹤谭璐瑩刘金平李平亚
Owner JILIN UNIV
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