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Combined medicine for preventing and/or repairing heart injuries caused by atmospheric pollution

A drug, prevention and control technology, applied in the direction of drug combination, anhydride/acid/halide active ingredients, medical preparations containing active ingredients, etc., can solve problems such as inconspicuous pollution control

Active Publication Date: 2021-09-14
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, PM 2.5 The overall control situation is gradually becoming clear, but pollution control is not obvious in the short term. Therefore, in some areas with serious air pollution, residents are affected by PM 2.5 Potential risk of coercion remains high

Method used

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  • Combined medicine for preventing and/or repairing heart injuries caused by atmospheric pollution
  • Combined medicine for preventing and/or repairing heart injuries caused by atmospheric pollution
  • Combined medicine for preventing and/or repairing heart injuries caused by atmospheric pollution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1 A kind of combined medicine

[0044] The combination medicine of embodiment 1 comprises A component and B component, and the composition (by weight) of A component and B component is respectively as follows:

[0045] Component A: 4.32 parts of taurine, 0.012 part of coenzyme Q10;

[0046] B component: α-linolenic acid 0.66 part, linoleic acid 0.1728 part, eicosapentaenoic acid (EPA) 0.2196 part, docosahexaenoic acid (DHA) 0.144 part.

[0047] The weight ratio of A component and B component is about 3.62:1.

[0048] The preparation method of component A is as follows: mixing taurine and coenzyme Q10 to obtain component A.

[0049] The preparation method of component B is as follows: α-linolenic acid, linoleic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are mixed to obtain component B.

Embodiment 2

[0050] Embodiment 2 A kind of combined medicine

[0051] The combination medicine of embodiment 2 comprises A component and B component, and the composition (by weight) of A component and B component is respectively as follows:

[0052] Component A: 2.16 parts of taurine, 0.006 part of coenzyme Q10;

[0053] B component: α-linolenic acid 0.99 part, linoleic acid 0.2592 part, eicosapentaenoic acid (EPA) 0.3294 part, docosahexaenoic acid (DHA) 0.216 part.

[0054] The weight ratio of A component and B component is about 1.21:1.

[0055] The preparation method of component A is as follows: mixing taurine and coenzyme Q10 to obtain component A.

[0056] The preparation method of component B is as follows: α-linolenic acid, linoleic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are mixed to obtain component B.

Embodiment 3

[0057] Embodiment 3 A kind of combination medicine

[0058] The combination medicine of embodiment 3 comprises A component and B component, and the composition (by weight) of A component and B component is respectively as follows:

[0059] Component A: 6.48 parts of taurine, 0.018 part of coenzyme Q10;

[0060] B component: α-linolenic acid 0.33 part, linoleic acid 0.0864 part, eicosapentaenoic acid (EPA) 0.1098 part, docosahexaenoic acid (DHA) 0.072 part.

[0061] The weight ratio of A component and B component is about 10.86:1.

[0062] The preparation method of component A is as follows: mixing taurine and coenzyme Q10 to obtain component A.

[0063] The preparation method of component B is as follows: α-linolenic acid, linoleic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are mixed to obtain component B.

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Abstract

The invention belongs to the technical field of medicines, and discloses a combined medicine for preventing and / or repairing heart injuries caused by atmospheric pollution. The combined medicine comprises a component A and a component B, wherein the component A comprises the following components: taurine and coenzyme Q10; and the component B comprises the following components: alpha-linolenic acid, linoleic acid, eicosapentaenoic acid and docosahexaenoic acid. The combined medicine can effectively eliminate the influence of PM2.5 exposure on the heart rate; the increase of active oxygen and inflammatory factors can be inhibited in the exposure process of PM2.5; and a certain inhibition effect is achieved on heart rate failure caused by PM2.5. The combined medicine can effectively eliminate myocardial cell morphology abnormity caused by PM2.5, inhibit collagen deposition, relieve a fibrosis degree and reduce the risk of heart failure diseases caused by PM2.5 exposure.

Description

technical field [0001] The invention belongs to the technical field of medicines, and particularly relates to a combined medicine for preventing and / or repairing heart damage caused by air pollution. Background technique [0002] PM in the atmosphere 2.5 Refers to fine particles with a diameter of 0.1 to 2.5 μm (according to aerodynamic diameter). Compared with other atmospheric particles, PM 2.5 The complex composition, huge quantity, small average particle size and large surface area make PM 2.5 surface can carry a lot of harmful and toxic substances (heavy metals, persistent organic pollutants, pathogenic microorganisms), so PM 2.5 The concentration of air pollution is one of the important indicators to evaluate air pollution. In addition to concentration, PM 2.5 Its chemical composition is also a key factor causing environmental pollution, and its main components include organic pollutants, soluble salts, metals, carbonaceous components and biological components. A...

Claims

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Application Information

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IPC IPC(8): A61K31/202A61K31/201A61K31/122A61K31/185A61P9/00A61P9/04
CPCA61K31/185A61K31/122A61K31/202A61K31/201A61P9/00A61P9/04A61K2300/00
Inventor 祁增华杨释疑蔡宗苇何晓翀黄一鸣林憶玲
Owner GUANGDONG UNIV OF TECH
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