Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of composition of hydroxysafflor yellow A and tenuigenin in preparation of medicine for treating cerebral arterial thrombosis

A technology of ischemic stroke, polygala saponin, applied in the field of medicine

Active Publication Date: 2021-09-07
SHANGHAI PUTUO DISTRICT CENT HOSPITAL
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there is no report on the improvement of ischemic stroke with the combined use of hydroxysafflower A and polygala saponin

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of composition of hydroxysafflor yellow A and tenuigenin in preparation of medicine for treating cerebral arterial thrombosis
  • Application of composition of hydroxysafflor yellow A and tenuigenin in preparation of medicine for treating cerebral arterial thrombosis
  • Application of composition of hydroxysafflor yellow A and tenuigenin in preparation of medicine for treating cerebral arterial thrombosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Purpose of the experiment

[0030] To explore the efficacy of hydroxysafflor yellow A combined with polygala saponin in improving ischemic stroke.

[0031] 2. Experimental materials

[0032] 2.1 Experimental animals

[0033] Healthy SPF grade male SD rats, aged 9-11 weeks, weighing 250-290 g, were purchased from Shanghai Slack Experimental Animal Company. The feeding and experimental process complied with the relevant working regulations of the Animal Ethics Committee (animal ethics committee review approval number: r20160302).

[0034] 2.2 Reagents and consumables

[0035] Chloral hydrate (Sinopharm Group), TTC staining agent (Beijing Xinong Science and Technology Co., Ltd.), MCAO silicone thread plug (A4) (Beijing Xinong Science and Technology Co., Ltd.), carotid artery injection syringe (Beijing Xinong Science and Technology Co., Ltd.), stainless steel Brain slicing blade (Beijing Xinong Technology Co., Ltd.).

[0036] 2.3 Instruments and equipment

[0037] ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an application of a composition of hydroxysafflor yellow A and tenuigenin in preparation of a medicine for treating cerebral arterial thrombosis. The medicine effect of hydroxysafflor yellow A and tenuigenin for improving cerebral arterial thrombosis is researched for the first time, the result shows that the degree of encephaledema can be reduced and the volume of cerebral infarction can be reduced through combined use of hydroxysafflor yellow A and tenuigenin, and the improvement effect on encephaledema and the improvement effect on cerebral infarction are obviously superior to those of hydroxysafflor yellow A and tenuigenin which are independently used; and the obvious synergistic effect is realized. The invention provides a novel medicine for treating cerebral arterial thrombosis.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of the composition of hydroxysafflor yellow A and polygala saponin in the preparation of medicine for treating ischemic stroke. Background technique [0002] Ischemic stroke is a cerebrovascular accident caused by the reduction or interruption of local blood supply to the brain tissue. The ischemic tissue will show symptoms of neurological deficits in the corresponding area, triggering a series of complex biochemical molecular cascade reactions, such as energy metabolism. Disorders, excitotoxic glutamate signaling pathway activation, free radical response, etc. These changes will trigger a series of inflammatory cascade reactions related to apoptosis and necrosis, leading to the destruction of cell integrity, and finally manifested as neuronal function damage. [0003] Hydroxysafflor yellow A (hydroxysafflor yellow A, HSYA) is a compound with a single chalcone glycoside s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61K31/351A61P9/10
CPCA61K31/56A61K31/351A61P9/10
Inventor 俞璐张秋娟张成刘知理贺文迪赵政曹晓华段燕红赵卿陶杰
Owner SHANGHAI PUTUO DISTRICT CENT HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com