Application of formononetin in preparation of drugs for preventing and treating myocardial infarction combined with depression

A technology for formononetin and depression, applied in the field of biomedicine, can solve the problems of physical and mental health threats of patients, increase the probability of adverse reactions of patients, etc., so as to avoid interactions and side effects, reduce the probability of adverse reactions, and promote expression. Effect

Active Publication Date: 2021-09-03
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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Problems solved by technology

However, there are often certain interactions and side effects in the combination of drugs, which increases the probability of adverse reactions in patients and threatens the physical and mental health of patients.

Method used

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  • Application of formononetin in preparation of drugs for preventing and treating myocardial infarction combined with depression
  • Application of formononetin in preparation of drugs for preventing and treating myocardial infarction combined with depression
  • Application of formononetin in preparation of drugs for preventing and treating myocardial infarction combined with depression

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Embodiment 1

[0044] Example 1 Establishment of Myocardial Infarction Complicated with Depression Mouse Model

[0045] (1) Animal grouping: 24 adult male C57BL / 6N mice were randomly divided into 3 groups, 8 in each group: the first group was the Sham group (sham operation group); the second group was the Model group (myocardial infarction combined with depression) group); the third group was the Model+formononetin group. Male C57BL / 6N mice in the Model+formononetin group underwent LAD ligation for 24 hours and then underwent chronic unpredictable stimulation for 10 days. The dosage is: 40mg / kg, intragastric administration 1 hour before ligation, and then continued intragastric administration for 10 days, once a day; the sham operation group and the myocardial infarction combined with depression group were given 0.2mL normal saline: propylene glycol = 1:1 solution by intragastric administration, Once a day.

[0046](2) Modeling method of myocardial infarction combined with depression: male...

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Abstract

The invention belongs to the field of biological medicines and discloses application of formononetin in preparation of drugs for preventing and treating myocardial infarction combined with depression. The formononetin can obviously improve depression symptoms and myocardial dysfunction of mice suffering from myocardial infarction combined with depression. The formononetin can improve hypomotion, thought retardation, hypoactivity of willpower and inappetence, resist heart tissue apoptosis and / or resist brain tissue inflammation, can obviously increase expression of 5-HT and BDNF in the hippocampus, reduce expression of IL-6 and IL-17A in the hippocampus and serum, inhibit expression of in-vivo and in-vitro macrophage and microglial cell M1 type markers and promote expression of M2 type markers. The invention creatively provides application of formononetin in preparation of drugs for preventing and treating myocardial infarction combined with depression, interaction and side effects existing in drug combination are avoided, the probability of adverse reactions of patients is reduced, and a basis is provided for clinical practice of treating myocardial infarction combined with depression by formononetin.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of formononetin in the preparation of drugs for preventing and treating myocardial infarction complicated with depression. Background technique [0002] Myocardial Infarction is one of the leading causes of death around the world, especially in developing countries. Myocardial infarction is usually a sudden illness that requires long-term rehabilitation. Depression is common in patients with myocardial infarction, approximately 40% of patients with myocardial infarction have depression. Depression is an independent risk factor for poor prognosis in patients with myocardial infarction, which increases the risk of myocardial infarction. Depression associated with myocardial infarction has negative effects on recovery, such as increased risk of myocardial infarction recurrence and mortality, and reduced medication adherence and quality of life. Therefore, time...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P9/10A61P25/24A61P1/14A61P9/00A61P25/00A61P9/04A61P29/00
CPCA61K31/352A61P9/10A61P25/24A61P1/14A61P9/00A61P25/00A61P9/04A61P29/00
Inventor 程媛媛杨莹陈思璇李旭平黄婷
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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