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Preparation method of water-soluble acanthopanax powder capsule

A kind of Acanthopanax senticosus, water-soluble technology, applied in capsule delivery, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. Limitations of drug routes and other issues, to achieve the effects of broadening drug routes and users, good palatability, and low development costs

Active Publication Date: 2021-08-31
NORTHEAST FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wherein although saponin is one of the main active components of Acanthopanax, but Acanthopanax saponins are not water-soluble, easily soluble in ethanol, which brings limitations to the processing and utilization of Acanthopanax saponins and the route of administration

Method used

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  • Preparation method of water-soluble acanthopanax powder capsule
  • Preparation method of water-soluble acanthopanax powder capsule

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preparation example Construction

[0039] The embodiment of the present invention discloses a water-soluble Acanthopanax senticosus powder capsule with simple preparation process, low processing cost, and capable of fully maintaining the activity of Acanthopanax senticosus saponins, and a preparation method thereof, which specifically includes the following steps:

[0040] In the present invention, the rhizome of Acanthopanax senticosus is used as raw material, after being air-dried, pulverized, and sieved through 20-60 meshes, it is extracted with 50-95% ethanol under reflux for 0.5-6 hours according to the material-liquid ratio of 1:10-1:40, and then subjected to 1000 Centrifuge at ~8000r / min for 5-30min to remove slag, collect supernatant Acanthopanax ethanol extraction solution, concentrate and recover ethanol through negative pressure, and obtain Acanthopanax concentrated extract;

[0041] Mix the concentrated extract of Acanthopanax acanthopanax and the water solution of the wall material according to the ma...

Embodiment 1

[0053] A preparation method of water-soluble Acanthopanax powder capsules, comprising the following steps:

[0054] 1) Take the rhizome powder of Acanthopanax senticosus as raw material, take fresh rhizome of Acanthopanax senticosus, air-dry, crush and pass through a 20-mesh sieve.

[0055] 2) Weigh a certain weight of Acanthopanax rhizome powder, use ethanol reflux extraction method, and use 50% ethanol according to the ratio of solid to liquid 1:15, reflux extraction for 3 hours.

[0056] 3) The extract obtained by the above extraction is centrifuged at 4000r / min for 10min in a centrifuge, and the residue is removed, the supernatant Acanthopanax ethanol extraction solution is collected, the ethanol is recovered through negative pressure concentration, and the Acanthopanax concentrated extract is obtained. Dry to constant weight at 105°C and measure the dry matter content.

[0057] 4) The chitosan oligosaccharide is configured into a wall material aqueous solution according ...

Embodiment 2

[0062] A preparation method of water-soluble Acanthopanax powder capsules, comprising the following steps:

[0063] 1) Using the rhizome powder of Acanthopanax senticosus as raw material, fresh rhizomes of Acanthopanax senticosus are obtained, air-dried, crushed and passed through a 40-mesh sieve.

[0064] 2) Weigh a certain weight of Acanthopanax rhizome powder, use ethanol reflux extraction method, and use 70% ethanol according to the ratio of solid to liquid 1:15, reflux extraction for 4 hours.

[0065] 3) The extract obtained by the above extraction is centrifuged at 6000r / min for 15min in a centrifuge, and the residue is removed, and the supernatant Acanthopanax ethanol extraction solution is collected, and the ethanol is recovered through negative pressure concentration to obtain the Acanthopanax concentrated extract. Dry to constant weight at 105°C and measure the dry matter content.

[0066] 4) The chitosan oligosaccharide is prepared into an aqueous solution of the w...

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Abstract

The invention discloses a preparation method of a water-soluble acanthopanax powder capsule, and belongs to the technical field of extraction and processing of plant rhizomes. According to the preparation method, the acanthopanax is taken as a raw material, saponin is dissolved out by adopting ethanol reflux extraction, and the water-soluble acanthopanax powder capsule is obtained through spray drying after being wrapped by chitosan oligosaccharide, so that the technological process is green, environment-friendly, simple and convenient to operate and good in dissolution property, and can be easily amplified to industrial production; a new thought is provided for development and utilization of water-soluble preparation of other Chinese herbal medicines insoluble in water, and the administration route and the use object are further widened; and in addition, the clathrate compound prepared by the invention is high in bioavailability, so that the curative effect of the clathrate compound is greatly improved, and the treatment cost is greatly reduced. Therefore, the technical scheme disclosed by the invention has great market application and popularization values.

Description

technical field [0001] The invention belongs to the technical field of extraction and processing of plant rhizomes, and in particular relates to a preparation method of water-soluble Acanthopanax powder capsules. Background technique [0002] Acanthopanax senticosus (Rupr. Maxim.) Harms is a plant of the genus Araliaceae of Araliaceae. Born in forests or shrubs, it likes a warm and humid climate, and is resistant to cold and shade. It is mainly distributed in Heilongjiang, Jilin, Liaoning, Hebei, and Shanxi. The main medicinal part of Acanthopanax is the underground part. As a traditional Chinese herbal medicine, it has been used for more than 2,000 years. It was first recorded in "Shen Nong's Materia Medica". Acanthopanax is listed as a top-grade traditional Chinese medicine, which has the effect of "invigorating the middle and replenishing Qi and strengthening the will". In addition, Acanthopanax has been included in the 2015 edition of "Pharmacopoeia of the People's Rep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/254A61K9/48A61K47/36A61P39/00A61K125/00
CPCA61K36/254A61K9/4816A61K47/36A61P39/00A61K2236/333A61K2236/51A61K2236/53
Inventor 路祺唐中华朱明华黄冬成包怡红于欣馨魏亮
Owner NORTHEAST FORESTRY UNIVERSITY
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