Application of iridoid compounds in the preparation of anti-coronavirus drugs

Abstract

The invention discloses the application of an iridoid compound in the preparation of an anti-coronavirus drug, which is characterized in that: the iridoid compound is cornel glucoside, berberine III or privetin. The iridoid compound of the scheme of the present invention has a good inhibitory effect on coronavirus, and has no obvious cytotoxicity, and can be prepared into medicine for clinical anti-coronavirus. The research and development of novel coronavirus drugs has clear scientific value and practical significance.

Description

technical field [0001] The invention belongs to the technical field of medicinal chemistry, and in particular relates to the application of iridoid compounds in the preparation of anti-coronavirus drugs. Background technique [0002] Human coronaviruses (HCoVs) are a class of RNA viruses with an envelope structure. Currently, there are seven main HCoVs infecting humans, namely HCoV-229E, HCoV-NL63, HCoV-OC43, SARS-CoV, MERS-CoV, HCoV-HKU1 and SARS-CoV-2 (Zhou P, Yang XL, Wang XG , et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 2020, Doi: 10.1038 / s41586-020-2012-7.). Among them, the outbreaks of Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and 2019 Novel Coronavirus (2019-nCoV or SARS-CoV-2) have brought severe challenges to social public health security. The current clinical treatment for HCoVs infection mainly focuses on improving symptoms. In terms of drug treatment, common antiviral dru...

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However, the other three HCoVs are more virulent and can cause symptoms of acute infection of the lower respiratory tract, and have a higher fatality rate in some critically ill patients

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