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Application of aspidopterys obcordata extract in medicine for preventing and/or treating uric acid nephropathy

A technology for uric acid nephropathy and uric acid nephropathy, which is applied in the field of drugs for the prevention and/or treatment of uric acid nephropathy. It can solve the problems that are not used to reduce renal inflammatory response, achieve good clinical application prospects, and reduce blood uric acid. Effect

Active Publication Date: 2021-08-06
云南省中医中药研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the use of the extract of Scutellaria chinensis for reducing blood uric acid and / or blood urea nitrogen in patients with uric acid nephropathy, and there is no report on reducing renal inflammatory response

Method used

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  • Application of aspidopterys obcordata extract in medicine for preventing and/or treating uric acid nephropathy
  • Application of aspidopterys obcordata extract in medicine for preventing and/or treating uric acid nephropathy
  • Application of aspidopterys obcordata extract in medicine for preventing and/or treating uric acid nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 The preparation of the extract of the vine of the present invention

[0023] Take 2g of the coarse powder of sifted through a 40-mesh sieve, add 18ml of dilute ethanol to soak for 1h, then reflux for 1h, extract 3 times in total, filter, combine the filtrate, and concentrate the filtrate to a thick liquid with a relative density of 1.4 (50°C). paste, and then placed in an oven at 80°C to dry into a dry extract, crushed, and passed through an 80-mesh sieve to obtain the product.

Embodiment 2

[0024] Example 2 The preparation of the extract of the vine of the present invention

[0025] Take 2g of the coarse powder of the sifted through a 40-mesh sieve, add 6ml of dilute ethanol to soak for 1h, then reflux for extraction for 1.5h, extract twice in total, filter, combine the filtrates, and concentrate the filtrates to a relative density of 1.4 (50°C). The thick paste is dried in an oven at 80°C to obtain a dry extract, crushed, and passed through an 80-mesh sieve to obtain the product.

Embodiment 3

[0026] Example 3 The preparation of the extract of the vine of the present invention

[0027] Take 2g of the coarse powder of the sifted through a 40-mesh sieve, add 12ml of dilute ethanol to soak for 1h, then reflux for 2h, extract 3 times in total, filter, combine the filtrate, and concentrate the filtrate to a thick liquid with a relative density of 1.5 (50°C). paste, and then put it in an oven at 80°C to dry it into a dry extract, crush it, and pass it through a 80-mesh sieve.

[0028] The beneficial effects of the present invention are illustrated below through test examples.

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Abstract

The invention discloses application of aspidopterys obcordata extract in preparation of a medicine with the effect of reducing blood uric acid, serum creatinine and / or blood urea nitrogen. Experiments prove that the aspidopterys obcordata dilute ethanol extract has the effects of remarkably reducing blood uric acid, serum creatinine and blood urea nitrogen, has a remarkable effect in the aspect of reducing kidney inflammatory response, can be used for treating uric acid nephropathy, and has a good clinical application prospect.

Description

technical field [0001] The present invention specifically relates to the use of the extract of Scutellaria saponifera in the medicine for preventing and / or treating uric acid nephropathy. Background technique [0002] Uric acid nephropathy is kidney damage caused by excessive production of blood uric acid or decreased excretion of hyperuricemia, commonly known as gouty nephropathy, clinical manifestations may include uric acid stones, small molecule proteinuria, edema, nocturia, hypertension, Elevated blood and urine uric acid and renal tubular dysfunction. If it can be diagnosed early and given appropriate treatment (controlling hyperuricemia and protecting renal function), renal disease can be alleviated or stopped developing. If treatment is delayed or improperly treated, the condition can worsen and develop into end-stage renal failure. Dialysis treatment is required. [0003] Aspidopterys obcordata Hemsl.var.obcordata is derived from the dried cane of Aspidopterys obc...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P19/06A61P13/12A61K135/00
CPCA61K36/185A61P19/06A61P13/12A61K2236/33A61K2236/39A61K2236/51
Inventor 张娅何鹏飞高敏赵远
Owner 云南省中医中药研究院
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