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Medical application of icaritin

A technology of icariin and drugs, applied in the field of medicine, can solve problems such as unclear composition and mechanism of action, and limited application

Pending Publication Date: 2021-08-03
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the traditional Chinese medicines for the clinical treatment of myelosuppression are compound preparations, and the main ingredients and mechanism of action are not clear, which greatly limits their application.

Method used

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  • Medical application of icaritin
  • Medical application of icaritin
  • Medical application of icaritin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1. Icaritin can increase the number of white blood cells and platelets in the peripheral blood of myelosuppressed mice

[0051] Experimental Materials:

[0052] 1. C57BL / 6J mice (leukocyte antigen phenotype is CD45.2): B6-Ly5.2 hereinafter referred to as C57, provided by the animal room of the Institute of Hematology, Chinese Academy of Medical Sciences.

[0053] All mice were kept in the SPF grade animal room of the Institute of Hematology, Chinese Academy of Medical Sciences. All the mice in this experiment were 8-10w weeks old, placed in sterile mouse cages, and the feed, drinking water, etc. were all sterilized by high temperature and high pressure, and there were no restrictions on feeding. Mice after intraperitoneal injection of cyclophosphamide were fed with water containing antibiotics (take 800 μL Bainoxin and add 300 mL drinking water) to prevent infection of mice.

[0054] experimental method:

[0055] 1. Solution preparation

[0056] A. Preparati...

Embodiment 2

[0069] Example 2. Icaritin can increase the proportion of hematopoietic stem and progenitor cells in the bone marrow of myelosuppressed mice, and enhance the hematopoietic and self-renewal abilities of hematopoietic stem cells

[0070] Experimental Materials:

[0071] 1. C57BL / 6J mice (leukocyte antigen phenotype is CD45.2): B6-Ly5.2 hereinafter referred to as C57, provided by the animal room of the Institute of Hematology, Chinese Academy of Medical Sciences.

[0072] 2. B6.SJL mice (leukocyte antigen phenotype is CD45.1): B6-Ly5.1 hereinafter referred to as B6, provided by the animal room of the Institute of Hematology, Chinese Academy of Medical Sciences.

[0073] The feeding conditions were the same as in Example 1, and the mice after bone marrow transplantation were fed with water containing antibiotics (800 μL of Biosin was added to 300 mL of drinking water) for 2 weeks to prevent infection of the mice.

[0074] experimental method:

[0075] 1. Dosing regimen: C57 mice...

Embodiment 3

[0143] Example 3. Icaritin can increase the number of bone marrow mesenchymal stem cells in bone marrow suppressed mice, promote its hematopoietic support ability, promote its osteogenic differentiation ability, and inhibit its adipogenic differentiation ability

[0144] Experimental Materials:

[0145] 1. C57BL / 6J mice (leukocyte antigen phenotype is CD45.2): B6-Ly5.2 hereinafter referred to as C57, provided by the animal room of the Institute of Hematology, Chinese Academy of Medical Sciences.

[0146] Raising condition is with embodiment one.

[0147] experimental method:

[0148] 1. Sorting mouse bone marrow microenvironment cells for single-cell transcriptome sequencing

[0149] A. The mice were killed by decapitation and soaked in 75% ethanol;

[0150] B. Remove the femur and tibia of the hind limb of the mouse, peel off the muscle tissue with sterile gauze, and put the bone into the pre-cooled PBS in advance;

[0151] C. Use fine scissors to cut the proximal end of ...

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Abstract

The invention relates to the field of medicine, and in particular, relates to a medical application of icaritin. The icaritin disclosed by the invention can be used for preventing and treating myelosuppression, increasing leukocytes and / or platelets, promoting proliferation of bone marrow hematopoietic stem cells, promoting proliferation of bone marrow mesenchymal stem cells, promoting osteogenic differentiation of the bone marrow mesenchymal stem cells and inhibiting adipogenic differentiation of the bone marrow mesenchymal stem cells.

Description

technical field [0001] The invention belongs to the field of medicine. It specifically relates to the application of icariin in the preparation of drugs for preventing and treating myelosuppression. Background technique [0002] Chemoradiotherapy is still one of the main means of treating malignant tumors, but it has a serious side effect of bone marrow suppression. The main clinical manifestation is the decrease of white blood cells, platelets and even whole blood cells in the peripheral blood of the patient, which seriously affects the continuation of radiotherapy and chemotherapy of the patient. At present, the drugs for treating myelosuppression mainly include biological agents and chemical drugs. While treating myelosuppression, biological agents can also cause severe side effects such as bone pain or allergies, while chemical drugs have unstable curative effects and their mechanisms of action are not clear. In recent years, traditional Chinese medicine has been gradu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K36/296A61P19/08A61P7/00A61K125/00
CPCA61K31/352A61K36/296A61P19/08A61P7/00
Inventor 张卫东景锐栾鑫吕超黄鹏里
Owner SHANGHAI UNIV OF T C M
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