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Method for improving antibacterial activity and biocompatibility of surface of base material

A biocompatible, substrate surface technology, applied in coatings, medical science, absorbent pads, etc., can solve problems such as threatening the health of patients, easily causing microbial infections, and economic losses.

Active Publication Date: 2021-07-30
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is easy to cause microbial infection during or after the implantation process. The source of infection includes bacteria and fungal pathogens, etc., which seriously threatens the health of patients and causes a lot of economic losses to the society.

Method used

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  • Method for improving antibacterial activity and biocompatibility of surface of base material
  • Method for improving antibacterial activity and biocompatibility of surface of base material
  • Method for improving antibacterial activity and biocompatibility of surface of base material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0178] Example 1: Lithium hexamethyldisilazide (LiHMDS) initiated N-ε-tert-butoxycarbonyl-DL-lysine-N-carboxyl anhydride and L-glutamic acid-5-benzyl ester Preparation of Random α-Amino Acid Copolymers with -N-Carboxyl Intracyclic Anhydrides

[0179] Lithium hexamethyldisilazide (33.4mg, 0.2mmol) was accurately weighed and prepared into a 0.1M solution with tetrahydrofuran (2mL) for later use. Weigh N-ε-tert-butoxycarbonyl-DL-lysine-N-carboxyl ring anhydride and L-glutamic acid-5-benzyl-N-carboxyl ring anhydride, and use tetrahydrofuran as a solvent. Take 1.8mL N-ε-tert-butoxycarbonyl-DL-lysine-N-carboxyl anhydride (0.2M) and 0.2mL-glutamic acid-5-benzyl ester-N-carboxyl anhydride (0.2M ) after mixing, add a magnet for stirring (taking monomer ratio x:y=9:1 as an example). Into a stirred reaction vial, add 0.8 mL of a 0.1 M lithium hexamethyldisilazide salt solution. The mixture was reacted with stirring at room temperature for 5 minutes in a glove box. After the polymer...

Embodiment 2

[0181] Example 2: Lithium hexamethyldisilazide (LiHMDS) triggers N-ε-tert-butoxycarbonyl-DL-lysine-N-carboxyl anhydride and DL-norleucine-N-carboxy Preparation of Random α-Amino Acid Copolymers with Intracyclic Anhydrides

[0182] The experimental method is the same as in Example 1, the difference is that DL-norleucine-N-carboxyl anhydride is replaced by L-glutamic acid-5-benzyl ester-N-carboxyl anhydride; The 0.1 M lithium hexamethyldisilazide salt solution was replaced by 0.8 mL of 0.1 M lithium hexamethyldisilazide salt solution. The obtained polymer had a molecular weight Mn=7500 g / mol and a molecular weight distribution Mw / Mn=1.19. The subunit ratio of the polymer was obtained by characterization by H NMR spectroscopy, and x:y=6.12:4 in the final polymer.

Embodiment 3

[0183] Example 3: Lithium hexamethyldisilazide (LiHMDS) triggers N-ε-tert-butoxycarbonyl-DL-lysine-N-carboxyl anhydride and DL-norvaline-N-carboxyl Preparation of Random α-Amino Acid Copolymers with Intracyclic Anhydrides

[0184] The experimental method is the same as in Example 1, the difference is that DL-norvaline-N-carboxyl anhydride is replaced by L-glutamic acid-5-benzyl ester-N-carboxyl anhydride; The 0.1 M lithium hexamethyldisilazide salt solution was replaced by 0.8 mL of 0.1 M lithium hexamethyldisilazide salt solution. The obtained polymer had a molecular weight Mn=7100 g / mol and a molecular weight distribution Mw / Mn=1.19. The subunit ratio of the polymer was obtained by H NMR spectrum characterization, and x:y=6:4 in the final polymer.

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Abstract

The invention provides a method for improving antibacterial activity and biocompatibility of the surface of a base material. Specifically, a common base material is pretreated and then chemically grafted with a polymer chain segment provided by the invention to form a functional surface with surface antibacterial activity. The modified functional surface shows high antibacterial activity to gram-negative bacteria and / or gram-positive bacteria and / or fungi, and meanwhile, the modified functional surface has low hemolytic activity to red blood cells, has excellent cell compatibility to mammalian cells, and shows long-acting antibacterial activity negligible toxicity after in-vivo implantation. Therefore, the modified surface has huge application potential in the field of biomedical materials, and an effective prevention and treatment means is provided for microbial surface infection.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a method for improving the antibacterial activity and biocompatibility of the substrate surface, so as to provide effective prevention and treatment means for microbial surface infection. Background technique [0002] With the increasing aging population and the continuous advancement of medical technology, biomedical materials (such as urinary catheters, intravenous indwelling catheters, cardiovascular stents) and medical devices (such as cardiac pacemakers, electrophysiological catheters, hip implants, The use of contact lenses) has also increased. However, it is easy to cause microbial infection during or after the implantation process. The source of infection includes bacteria and fungal pathogens, etc., which seriously threatens the health of patients and causes a lot of economic losses to the society. According to statistics, tens of millions of people die from infectious...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/04C08J9/42C03C17/34A61L27/54A61L31/16A61L15/46C08L75/04C08L61/16
CPCC08J7/0427C08J9/42C03C17/3405A61L27/54A61L31/16A61L15/46C08J2375/04C08J2361/16C03C2218/111
Inventor 刘润辉武月铭
Owner EAST CHINA UNIV OF SCI & TECH
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