Composition capable of reducing uric acid and dissolving uric acid crystals and tophus and application of composition

Abstract

The invention provides a composition capable of reducing uric acid and dissolving uric acid crystals and tophus and application of the composition. The composition comprises a probiotic composition and prebiotics, wherein the probiotic composition is one or more of lactobacillus reuteri, lactobacillus fermentum, bacillus coagulans, lactobacillus rhamnosus, lactobacillus casei and lactobacillus plantarum, and the mass ratio of the probiotic composition to the prebiotics is (1-80):(1-80). The probiotic composition and the prebiotics are combined, the prepared compound bacterium powder can remarkably reduce blood uric acid of gout patients, and the crystal dissolving effect of the compound bacterium powder is verified through dual-energy CT for the first time.

Description

technical field [0001] The invention relates to the technical field of prevention and treatment of hyperuricemia and gout, in particular to a composition capable of lowering uric acid, dissolving uric acid crystals and tophi and its application. Background technique [0002] Gout is a crystal-associated arthropathy caused by monosodium urate deposition, which is directly related to hyperuricemia caused by purine metabolism disorder and decreased uric acid excretion, and belongs to the category of metabolic rheumatism. The clinical symptoms of gout are severe pain, edema, redness, and inflammation in the joints. The first attack usually involves a single joint, the most common being the first metatarsophalangeal joint, and subsequent attacks can involve the dorsum of the foot, ankle, heel, knee, and wrist. , fingers, elbows and other joints, accompanied by fever; 3-14% of the first attack involved multiple joints; acute gout rarely involved shoulder joints, hip joints, spine,...

AI Technical Summary

Problems solved by technology

However, the above-mentioned drugs cannot solve the fundamental cause of these gouts, they can only simply inhibit the activity of xanthine oxidase, inhibit the reabsorption capacity of URAT1, increase the secretion activity of ABCG2, and degrade blood uric acid; moreover, these drugs dissolve the deposited uric acid Crystals and tophi have harsh conditions, and it is necessary to keep blood uric acid below 360 μmol / L; in addition, these drugs have great damage to the liver and kidneys, and cannot be used more often or for a long time. Many patients give up using this drug because they cannot bear the side effects. drugs for treatment

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