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High-efficiency self-healing hydrogel enhanced by cellulose nanocrystals and preparation method thereof

A technology of nanocrystals and cellulose, applied in the field of highly efficient self-healing hydrogels reinforced by cellulose nanocrystals and its preparation, can solve the problems of unsatisfactory biocompatibility and poor self-healing performance of hydrogels, etc. Achieve the effect of improving biocompatibility, high swelling performance and high water absorption rate

Active Publication Date: 2022-07-05
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the self-healing rate of the hydrogel is only 60% under pH stimulation, and the self-healing performance is poor.
In addition, the biocompatibility of the hydrogel is still not ideal due to the use of initiators and olefin-based monomer raw materials

Method used

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  • High-efficiency self-healing hydrogel enhanced by cellulose nanocrystals and preparation method thereof
  • High-efficiency self-healing hydrogel enhanced by cellulose nanocrystals and preparation method thereof
  • High-efficiency self-healing hydrogel enhanced by cellulose nanocrystals and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0042] The present invention also provides a preparation method of a cellulose nanocrystal-enhanced high-efficiency self-healing hydrogel, comprising the following steps:

[0043] S1. Preparation of hydrazide-modified hyaluronic acid with disulfide bonds;

[0044] Dissolve a certain amount of hyaluronic acid in deionized water, prepare a solution with a mass-to-volume ratio of 1g:(20-200)ml, and then add carbodiimide (EDC), activation auxiliary (NHS) and 3,3 '-dithiodipropionic hydrazide; wherein, the molar ratio of hyaluronic acid and carbodiimide (EDC) is 1:(0.1~15), and the molar ratio of carbodiimide and activation auxiliary agent is 1:( 0.1~10), the molar ratio of hyaluronic acid and 3,3`-dithiodipropionyl hydrazide is 1:(1~15); then react at 25~50℃ for 1~24h, then dialyze with deionized water 1 to 3d, and then freeze-drying at -50 to -80° C. and 1 to 80 Pa to obtain hydrazide hyaluronic acid with a degree of substitution of 0.1 to 0.8.

[0045] S2. Prepare cellulose na...

Embodiment 1

[0053] A cellulose nanocrystal-enhanced high-efficiency self-healing hydrogel is prepared by the following steps:

[0054] S1. Preparation of hydrazide-modified hyaluronic acid with disulfide bonds

[0055] Dissolve a certain amount of hyaluronic acid in deionized water, prepare a solution with a mass-to-volume ratio of 1g:100ml, and then add carbodiimide (EDC), activation aid (NHS) and 3,3′-dithiol Dipropionyl hydrazide; wherein, the molar ratio of hyaluronic acid and carbodiimide (EDC) is 1:0.5, the molar ratio of carbodiimide and activation adjuvant is 1:0.5, and the molar ratio of hyaluronic acid and 3,3` -The molar ratio of dithiodipropionyl hydrazide is 1:5; then react at 25~50℃ for 1~24h, dialyze with deionized water for 1~3d, then at -50~-80℃, 1~80Pa Freeze-drying is carried out under conditions to obtain hydrazide hyaluronic acid with a degree of substitution of about 0.5.

[0056] S2. Prepare cellulose nanocrystal dispersion with aldehyde groups with a mass concent...

Embodiment 2-7 and comparative example 1

[0066] Compared with Example 1, the high-efficiency self-healing hydrogels reinforced by cellulose nanocrystals provided in Examples 2-7 and Comparative Example 1 are different in that the aldehyde-ylated cellulose nanocrystals prepared in step S2 have The lengths and diameters are shown in Table 1. Others are substantially the same as those in Embodiment 1, and are not repeated here.

[0067] Table 1 Preparation conditions and performance test results of Examples 1-7 and Comparative Example 1

[0068]

[0069] It can be seen from Table 1 that with the increase of the aspect ratio, the water absorption of the hydrogel first increases and then decreases, and the strength first increases and then decreases, but the self-healing efficiency gradually decreases; with the increase of the overall size The strength of the hydrogel tends to decrease gradually, which may be the result of the co-determination of the content of aldehyde groups on the crystal surface and the size of th...

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Abstract

The invention provides a high-efficiency self-healing hydrogel reinforced by cellulose nanocrystals and a preparation method thereof. The high-efficiency self-healing hydrogel includes a hydrazide-modified hydrogel matrix material with a disulfide bond and a cellulose nanocrystal with an aldehyde group that forms a cross-linked network structure therewith. Wherein, the cellulose nanocrystals with aldehyde groups have a length of 3-1000 nm, a diameter of 3-500 nm, and an aspect ratio of (1-20):1. The cross-linking of such cellulose nanocrystals with aldehyde groups and hydrazide-modified hydrogel matrix materials with disulfide bonds can form three-dimensional cross-links with cellulose nanocrystals with aldehyde groups as the cross-linking center The network structure, the cross-linked network structure and the disulfide bond-containing Schiff base structure synergistically improve the strength, self-healing efficiency and self-healing recovery rate of the hydrogel.

Description

technical field [0001] The invention relates to the technical field of self-healing hydrogels, in particular to a high-efficiency self-healing hydrogel reinforced by cellulose nanocrystals and a preparation method thereof. Background technique [0002] As a soft three-dimensional network polymer, self-healing hydrogel is an ideal tissue scaffold because of its microstructure and physicochemical properties are very similar to extracellular matrix, and it can restore its structure and performance after injury. thereby prolonging its service life. Therefore, self-healing hydrogels are an ideal biological substitute and have great application value in the field of biomedicine. [0003] In recent years, based on the principle of biomimicry, researchers have fabricated self-healing hydrogels using reversible dynamic covalent bonds and reversible dynamic non-covalent cross-linking. Chen et al. (Ultratough, self-healing, and tissue-adhesivehydrogel for wound dressing. ACS applied ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/08C08L1/04
CPCC08J3/075C08J3/246C08J2305/08C08J2401/04C08J2301/04C08J2405/08
Inventor 周应山李尚志万婷婷范朋珲杨红军顾绍金叶德展陶咏真徐卫林
Owner WUHAN TEXTILE UNIV
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