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Application of lycium barbarum polysaccharide in preparation of anti-fatigue drugs, health care products or food

A technology of Lycium barbarum polysaccharide and health care product, applied in the field of medicine, can solve the problems of affecting biological activity and the like

Inactive Publication Date: 2021-07-16
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the molecular weight of natural polysaccharides is closely related to its absorption and transportation in the body, thus affecting biological activity

Method used

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  • Application of lycium barbarum polysaccharide in preparation of anti-fatigue drugs, health care products or food
  • Application of lycium barbarum polysaccharide in preparation of anti-fatigue drugs, health care products or food
  • Application of lycium barbarum polysaccharide in preparation of anti-fatigue drugs, health care products or food

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Experimental materials

[0027] 1.1 Materials and reagents

[0028] Glycogen, urea nitrogen (BUN), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and malondialdehyde (MDA) assay kit (Nanjing Jiancheng Bioengineering Institute); Lycium barbarum (from Sannong Traditional Chinese Medicine Planting Farmers' Cooperative, Jinzhong Town, Zhangxian County, Dingxi City, Gansu Province), American Ginseng Oral Liquid (each 100mL contains: total saponins (calculated as ginsenoside Re) 230mg, Fujian Lifik Pharmaceutical Co., Ltd.)

[0029] 1.2 Experimental Instruments

[0030] UV-Vis spectrophotometer (Lambda 35, PerkinElmer Inc., USA); multi-functional microplate reader (Tecan infinite 200pro, Tecan Austria GmbH company)

[0031] 1.3 Experimental animals

[0032] Male ICR mice (20±2g) were purchased from the Comparative Medicine Center of Yangzhou University, and the animal certificate number is SCXK (Su) 2017-0007. The mice were acclimatized for one week at 25°...

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Abstract

The invention discloses application of lycium barbarum polysaccharide in preparation of anti-fatigue drugs, health care products or food. The lycium barbarum polysaccharide with the molecular weight of 92.4 kDa can obviously increase the reserve of hepatic glycogen and muscle glycogen, improve the activity of superoxide dismutase and obviously reduce the levels of serum urea nitrogen, blood lactic acid and malondialdehyde; and compared with lycium barbarum polysaccharide with other molecular weights, the lycium barbarum polysaccharide has a more excellent anti-fatigue effect and is suitable for preparing anti-fatigue drugs, health care products or food.

Description

technical field [0001] The invention belongs to the technical field of medicines and relates to the application of Lycium barbarum polysaccharides in the preparation of anti-fatigue medicines, health care products or food. Background technique [0002] Fatigue is a normal physiological phenomenon that occurs when the body is engaged in mental or physical activities due to excessive consumption to a certain extent. Fatigue often leads to a range of secondary problems, such as depression and anxiety, and is also associated with cognitive impairment, poor sleep quality, physical dysfunction and energy imbalance. Chronic fatigue increases the risk of cancer, multiple sclerosis, HIV infection and Parkinson's disease. Eliminating and relieving fatigue has always attracted the attention of fields such as sports medicine, military medicine and aerospace medicine. Fatigue is a complex and common physiological phenomenon without a clear cause. Long-term medication may be required, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K36/815A61P39/00A61P7/00A61P3/08C08B37/00A23L33/125A61K131/00
CPCA61K31/715A61K36/815A61P39/00A61P7/00A61P3/08C08B37/0003A23L33/125A23V2002/00A61K2236/333A61K2236/39A61K2236/53A61K2236/51
Inventor 刘国艳杨雪缪凤吉涛梁丽张继贤徐鑫
Owner YANGZHOU UNIV
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