High-cleanliness biopharmaceutical sterile liquid operation platform based on magnetic suspension technology

Abstract

The invention relates to the technical field of cellular immunotherapy, and especially relates to a high-cleanliness biopharmaceutical sterile liquid operation platform based on a magnetic suspension technology. The operation platform comprises a magnetic suspension motion platform and a sterile liquid operation cabin, the magnetic suspension motion platform comprises a clean cabin external mechanism and a clean cabin internal mechanism, the clean cabin external mechanism comprises a magnetic suspension stator fixing support, a magnetic suspension stator assembly, a motion controller and a cabin isolation plate, and the clean cabin internal mechanism comprises a magnetic suspension rotor, a magnetic suspension rotor sealing protection shell, a rotor upper consumable material carrying frame, a magnetic suspension rotor positioning mark and an intelligent camera. The sterile liquid operation cabin comprises a magnetic suspension platform, a sterile robot, an injector operation unit, a consumable temporary storage frame and a centrifugal machine. A whole operation method is simple and convenient, and the overall practicability is high.

Description

technical field [0001] The invention relates to the technical field of cellular immunotherapy, in particular to a high-cleanness biopharmaceutical aseptic liquid operating platform based on magnetic levitation technology. Background technique [0002] The rapid development of cellular immunotherapy technologies, such as CAR-T, TCR-T, (sc)TIL, etc., requires large-scale production in the clinical treatment process to meet the needs of the majority of patients. In order to achieve better therapeutic effect and higher treatment safety, autologous cell therapy will be a main form of cell therapy. Autologous cell therapy cell samples are obtained from the patients themselves, and the cells of different patients have great differences and fluctuations, requiring manual or simulated complex operations to meet the complex needs of individualized production of different patients in the production process. In order to meet the demand of huge production volume, the fully automatic ope...

AI Technical Summary

Problems solved by technology

Realized by the traditional movement method, it needs to use a large number of screw rods, racks and pinions, cylinders and other executive structures to realize material handling and precise operation, which brings many risks of aseptic safety and closed cleaning: 1) During the movement The dust generated by mechanical structure friction becomes the carrier of polluting microorganisms; 2) The moving parts have many complex contact surfaces, and the dead angle is not conducive to the effective contact and deep sterilization of the gasification sterilant, and it is easy to produce the residue of the sterilant on the complex surface ;3) The complex motion mechanism cannot ensure that personnel can effectively clean the dead corners of the complex motion system during regular cleaning, and personnel cleaning is likely to cause potential damage to the precision structure; 4) The traditional motion structure is suitable for curing processes 5) The space structure of the traditional mechanical structure is relatively complex, which is not conducive to the formation and maintenance of the key laminar flow pattern in the closed laminar flow space

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