Hydrophobic drug solubilizing method based on cation-pi action
A hydrophobic drug and cationic technology, applied in the field of medicine, can solve the problems of toxicity, poor stability of solid dispersion, drug precipitation and other problems, and achieve the effect of simple method, high solubility and good safety
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[0019] Experimental conditions:
[0020] Normal temperature (25°C) normal pressure (1 standard atmospheric pressure)
[0021] experimental method:
[0022] 1. Prepare an ethanol solution of quercetin with a known and definite concentration.
[0023] 2. Prepare an aqueous solution of quercetin with a saturated unknown concentration.
[0024] 3. ZnCl 2 Dissolve in water, configure ZnCl with a concentration of 0.125mol / l~2mol / l 2 aqueous solution, the AlCl 3 Dissolve in water and prepare AlCl with a concentration of 0.3125mol / l~0.5mol / l 3 Aqueous solution; quercetin concentration is 0.1mg / ml (ethanol), quercetin and ZnCl 2 and AlCl 3 Mix them separately and place them in a lyophilizer to drain the ethanol to obtain an aqueous solution of the mixture. The ultraviolet absorption spectrum of the aqueous solution of the mixture is detected by ultraviolet spectroscopy (U-2900, HITACHI, JAPAN). Solution A is an aqueous solution of quercetin, solution B is Zn 2+ + quercetin; C ...
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