Hollow copper sulfide nano-drug carrier, and preparation method and application thereof

A nano-drug carrier, copper sulfide technology, applied in the direction of drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve the problems of unfavorable internal circulation, poor hydrophilicity, reagent toxicity, etc., achieve uniform size distribution, low cost, and low toxicity Effect

Inactive Publication Date: 2021-07-09
WUHAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In summary, the existing copper sulfide nano-drug carriers have disadvantages such as poor hydrophilicity, large size, which is not conducive to internal circulation and high toxicity of reagents during the preparation process.

Method used

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  • Hollow copper sulfide nano-drug carrier, and preparation method and application thereof
  • Hollow copper sulfide nano-drug carrier, and preparation method and application thereof
  • Hollow copper sulfide nano-drug carrier, and preparation method and application thereof

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Embodiment

[0037] A hollow copper sulfide nano drug carrier, its preparation method and application. The steps of the preparation method described in this embodiment are:

[0038] Step 1. At room temperature, disperse 34.2 mg of copper chloride dihydrate and 200.0 mg of polyvinylpyrrolidone (molecular weight 10,000) in water, and stir for 5 minutes to obtain a mixed solution A; (the copper chloride dihydrate: the The ratio of the amount of polyvinylpyrrolidone is 1:0.1).

[0039] Step 2, in the mixed solution A, dropwise add the 0.2M sodium hydroxide solution of 4mL, stir 5 minutes, obtain the mixed solution B; (the copper chloride dihydrate: in the described sodium hydroxide solution The ratio of the amount of sodium hydroxide to the substance is 1:4).

[0040] Step 3, in described mixed solution B, dropwise add the ascorbic acid solution of 4mL 0.1M, stir 5 minutes, obtain mixed solution C; The amount ratio is 1:2).

[0041] Step 4. Add 4 mL of 1.0 M sodium sulfide solution dropwis...

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Abstract

The invention discloses a hollow copper sulfide nano-drug carrier, and a preparation method and application thereof. According to a technical scheme in the invention, copper chloride dihydrate, polyvinylpyrrolidone, sodium hydroxide, ascorbic acid and sodium sulfide are used as raw materials, and black solid hollow copper sulfide nanoparticles are prepared; and the prepared hollow copper sulphide nanoparticles are complexed with a tumor chemotherapeutic drug, namely a tetravalent platinum drug, and modified amino functionalized polyethylene glycol terminal methyl ether under the coordination action of a copper element and a nitrogen element to obtain the hollow copper sulfide nano-drug carrier. The preparation method has the characteristics of simplicity in operation, high safety, mild reaction conditions, controllable reaction process and low cost; and the prepared hollow copper sulfide nano-drug carrier is good in hydrophilicity, small in size, favorable for in-vivo circulation and low in reagent toxicity in a preparation process.

Description

technical field [0001] The invention belongs to the technical field of nano drug carrier. The matrix relates to a hollow copper sulfide nano medicine carrier, a preparation method and an application. Background technique [0002] Photothermal therapy (PTT), which uses light absorbers to convert light energy into heat, can induce thermal ablation of cancer cells, which has been increasingly recognized as an effective complement to conventional cancer treatments. As light absorbers, various nanomaterials with high absorbance can be used in PTT, including noble metal nanomaterials, carbon-based nanomaterials, and semiconductor nanomaterials, etc. In recent years, photothermally responsive nanomaterials induced by near-infrared light (700-1100nm) (NIR) have attracted extensive attention due to their advantages of high safety and strong penetrability. Currently, many nanomaterials as photothermal agents with strong absorption capacity for near-infrared light have been extensive...

Claims

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Application Information

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IPC IPC(8): A61K47/02A61K47/32A61K47/18A61K41/00A61P35/00A61K33/243
CPCA61K47/02A61K47/32A61K47/18A61K41/0052A61K41/0057A61K33/243A61P35/00A61K2300/00
Inventor 邹涛陈全兵朱帅杨锰董志军
Owner WUHAN UNIV OF SCI & TECH
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