Medicine composition applied to chemotherapy of tumors

Abstract

The invention discloses a medicine composition applied to chemotherapy of tumors, and particularly discloses application of sildenafil serving as an antitumor medicine sensitizer to preparation of chemotherapy medicines for tumors. According to the invention, sildenafil is used as the sensitizer, and sildenafil is combined with anti-tumor drugs such as oxaliplatin, irinotecan or capecitabine through a carrier to prepare the anti-tumor composition which can be used for effectively killing tumor cells such as colorectal cancer or drug-resistant tumor cells. According to the application, the sensitization effect of sildenafil on antitumor drugs is verified at a cellular level for the first time, the treatment synergistic effect of sildenafil serving as the sensitizer in cancers such as colorectal cancer, gastric cancer, liver cancer, breast cancer and prostatic cancer is verified, and a new way and means are provided for effectively treating tumors.

Description

technical field [0001] The invention relates to the field of medicine, and relates to a combination of tumor chemotherapy drugs, in particular to the use of sildenafil as an antitumor drug sensitizer in the preparation of tumor chemotherapy drugs. Background technique [0002] Colorectal cancer, gastric cancer, liver cancer, breast cancer, prostate cancer and other tumors seriously threaten human life and health, and their morbidity and mortality are high. Diagnosis and treatment of colorectal cancer, gastric cancer, liver cancer, breast cancer, and prostate cancer are major public health problem. At present, the main treatment methods for colorectal cancer, gastric cancer, liver cancer, breast cancer, prostate cancer and other tumors include surgery, chemotherapy and radiation therapy. For patients with early detection, surgical resection is considered a better treatment; however, when the tumor progresses to an advanced stage, surgical treatment alone cannot cure the tumo...

AI Technical Summary

Problems solved by technology

For patients with early detection, surgical resection is considered a better treatment; however, when the tumor progresses to an advanced stage, surgical treatment alone cannot cure the tumor, and systemic chemotherapy or chemotherapy-assisted surgical treatment is required to treat the disease. patient treatment

However, for the chemotherapeutic drugs routinely used in the related art, most of the chemotherapeutic drugs have certain toxicity and side effects, such as myelosuppression, reduction of white blood cell count, inhibition of platelets, diarrhea, nausea, vomiting, etc. Hazardous

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