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Composition containing picea melanocarpa extract and sleep-aiding product

A composition and extract technology are applied in the fields of compositions and sleep aid products containing black spruce extract, which can solve the problems of not finding the application of black spruce essential oil, and achieve shortening sleep latency, increasing expression, and increasing quantity Effect

Inactive Publication Date: 2021-07-09
HUAANTANG BIOTECH GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of black spruce essential oil in the field of sleep aid has not been found so far

Method used

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  • Composition containing picea melanocarpa extract and sleep-aiding product
  • Composition containing picea melanocarpa extract and sleep-aiding product
  • Composition containing picea melanocarpa extract and sleep-aiding product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] This embodiment is the preparation of essential oil composition

[0046] Mix vetiver essential oil, black spruce essential oil and true lavender essential oil in mass ratios of 35:40:380, 50:50:500, and 65:60:620 to obtain essential oil compositions, which are respectively recorded as test composition 1, test Composition 2 and Test Composition 3.

Embodiment 2

[0051] This embodiment uses chlorphenylalanine (PCPA) to establish a mouse model of insomnia

[0052] Modeling was started after the mice were adaptively fed for one week. The p-chlorophenylalanine PCPA suspension is prepared and used now, 600mg of PCPA powder is dissolved in 20mL of physiological saline containing 1% Tween80, and the prepared concentration is 30mg / mL. Except for the blank control group, the other groups were intraperitoneally injected at a dose of 0.1 mL / 10 g of mouse body weight, and the blank control group was intraperitoneally injected with the same volume of normal saline containing 1% Tween for 2 consecutive days. 26-30h after the end of the last intraperitoneal injection of PCPA, the mice showed behavioral changes (non-stop activities during the day, increased excitability, irritability, disappearance of circadian rhythm, increased water intake and food intake, and significantly reduced sleep time), indicating that The insomnia model was successfully b...

Embodiment 3

[0054] This embodiment verifies the sleep-aiding effect of the sleep-aid composition

[0055] 1. Using pentobarbital sodium animal sleep time test to detect the effect of essential oil composition on sleep latency and sleep time of sleeping mice

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Abstract

The invention relates to the technical field of plant extracts, in particular to a composition containing a picea melanocarpa extract and a sleep-aiding product. The invention discloses a composition. According to the sleep-aiding composition, a spruce schefflera extract, vetiver essential oil and real lavender essential oil are matched with one another, so that the sleep latency duration of a mouse in a pentobarbital sodium induced sleep experiment can be shortened, and the sleep time can be prolonged; the number of mouse hippocampal neurons is increased; the expression quantity of 5HT-1A protein and GABAAR[alpha]1 protein in each region of the brain is improved. The sleep-aiding composition has a remarkable sleep-aiding effect.

Description

technical field [0001] The invention relates to the technical field of plant extracts, in particular to a composition containing black spruce extract and a sleep aid product. Background technique [0002] With the increasing pressure of life, people's sleep quality cannot be guaranteed, which has seriously affected normal work and study. [0003] At present, the methods for treating insomnia mainly include drug therapy and non-drug therapy. Drug treatment of insomnia is the most effective method, but drug treatment also has side effects such as drug dependence and drug withdrawal reaction. [0004] Non-drug treatments mainly include aromatherapy, etc. The medicinal ingredients used in aromatherapy are mainly plant extracts. Although the therapeutic effect of aromatherapy using plant extracts is not as fast as that of drugs, the advantage is that the plant extracts are pure and safe, and there are almost no side effects such as drug dependence and drug withdrawal reactions....

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K36/15A61K8/9767A61K8/92A61P25/20A61Q19/00
CPCA61K36/15A61K36/899A61K36/53A61K9/007A61K9/0014A61P25/20A61K8/9767A61K8/922A61Q19/00A61K2800/5922A61K2300/00
Inventor 唐明慧艾勇张炽坚宋妮朱思阳何廷刚
Owner HUAANTANG BIOTECH GRP CO LTD
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