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Method for evaluating multiple types of cardiotoxicity of tumor patients

A technology for patients with cardiotoxicity and tumors, applied in pathological reference, health index calculation, medical simulation, etc., can solve problems such as limited evaluation factors, increased risk of cardiotoxicity, and negative effects on the heart

Pending Publication Date: 2021-07-06
FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The incidence of ifosfamide-induced LVD is less than 1%, and a single large dose (>12.5g / m 2 ) will significantly increase the risk of cardiotoxicity
[0014] The Mayo score has a certain guiding role in clinical practice, but more and more studies have shown that most antineoplastic drugs will have a negative impact on the heart, and different treatment options will produce different types of cardiovascular toxicity, and the degree of toxicity varies. will be differentiated
However, the evaluation factors involved in the Mayo cardiotoxicity score are limited, and only the risk classification of cardiac insufficiency is made, and the evaluation recommendations are relatively general, which has great limitations in the actual diagnosis and treatment guidance for patients.

Method used

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  • Method for evaluating multiple types of cardiotoxicity of tumor patients
  • Method for evaluating multiple types of cardiotoxicity of tumor patients
  • Method for evaluating multiple types of cardiotoxicity of tumor patients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] A 75-year-old female breast cancer patient has completed four cycles of AC-T regimen treatment and is in the stage of single-drug docetaxel chemotherapy. According to its clinical data, the risk factors and scores related to cardiotoxicity can be listed, and the total score and risk degree can be calculated. details as follows:

[0099] 1. Cardiac insufficiency

[0100]

[0101] 2. Coronary artery disease

[0102]

[0103] 3. Hypertension

[0104]

[0105] 4. Arrhythmia

[0106]

[0107] 5. Stroke and Thrombosis

[0108]

[0109] 6. Prolonged QT interval

[0110]

[0111] To sum up, because the patients in Example 1 have a high-risk rating, the overall rating is determined as a high-risk rating. According to its overall rating, the recommendations corresponding to the high-risk rating are given as follows: transthoracic echocardiography with strain before chemotherapy, every 3 cycles of chemotherapy, at the end, 3-6 months after the end, and 1 ye...

Embodiment 2

[0113] A 57-year-old male patient with colon cancer, more than 3 years after surgery for colon cancer, found extensive abdominal metastases for 2 years, and was admitted to the hospital for treatment. According to its clinical data, the risk factors and scores related to cardiotoxicity can be listed, and the total score and risk degree can be calculated. details as follows:

[0114] 1. Cardiac insufficiency

[0115]

[0116] 2. Coronary artery disease

[0117]

[0118] 3. Hypertension

[0119]

[0120] 4. Arrhythmia

[0121]

[0122] 5. Stroke and Thrombosis

[0123]

[0124] 6. Prolonged QT interval

[0125]

[0126] To sum up, because the patient in Example 2 has a high-risk rating, the overall rating is determined as a high-risk rating. According to its overall rating, the recommendations corresponding to the high-risk rating are given as follows: transthoracic echocardiography with strain before chemotherapy, every 3 cycles of chemotherapy, at the e...

Embodiment 3

[0128] The present invention fully excavates and analyzes the medical data of cancer patients, and trains an analysis model. In this embodiment, the analysis model is used to evaluate the cardiotoxicity of cancer patients, so as to prevent and reduce the cardiac damage caused by cancer treatment. toxicity. The analysis model can be updated regularly with the accumulation of medical data of cancer patients, making the evaluation results more and more accurate. It can also evaluate and predict the cardiotoxicity of patients diagnosed with cancer, so as to assist medical staff in minimizing cardiotoxicity. Under the premise of formulating the optimal treatment plan.

[0129] Such as Figure 9 It is a method for establishing a cardiotoxicity assessment model for cancer patients and a calibration and optimization method provided in the embodiment of the present application, and the method includes the following steps.

[0130] S1. Obtain baseline data and cardiotoxicity results o...

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Abstract

The invention provides a method for evaluating various types of cardiotoxicity of tumor patients, and for the tumor patients, the evaluation factors related to the existing Meio cardiotoxicity scoring are limited, and the evaluation suggestions are general. According to the method provided by the invention, risk factors which have been researched and proved to have influences on cardiotoxicity are introduced, values are assigned to the risk factors according to the correlation degrees of the risk factors and various cardiotoxicity risks, an evaluation model is established by referring to a Meio scoring system, risk grading is carried out on the six types of cardiotoxicity, and corresponding evaluation suggestions are given; and according to the method, an existing evaluation system is expanded, the blank of domestic cardiotoxicity evaluation is filled, and reliable basis and suggestions are provided for clinicians to treat and follow up tumor patients.

Description

technical field [0001] The invention relates to a medical scale evaluation method, in particular to a multi-type cardiac toxicity evaluation method for tumor patients. Background technique [0002] Cardiotoxicity in cancer patients refers to heart disease caused by cancer drugs or radiotherapy that can have toxic effects on the myocardium and / or cardiac electrical conduction system after cancer patients receive treatment. In recent years, with the continuous update and progress of early diagnosis and treatment strategies of tumors, the survival period of tumor patients has been prolonged, but the morbidity and mortality of cardiotoxicity caused by anticancer treatment have increased year by year. It is one of the most common diseases in the treatment-induced adverse reactions, which has a huge negative impact on the health recovery and quality of life of patients in the prognostic stage. (Reference: Xia Yunlong, Liu Jiwei, et al. Handbook of Oncology and Cardiology Treatmen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/50G16H50/20G16H50/30G16H50/70G16H70/60
CPCG16H50/50G16H50/20G16H50/30G16H50/70G16H70/60
Inventor 夏云龙刘基巍刘莹方凤奇陈艳伟杨晓蕾
Owner FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
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