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High-internal-phase beta-carotene nano-emulsion as well as preparation method and application thereof

A carotene and nanoemulsion technology, applied in application, emulsion delivery, pharmaceutical formulation, etc., can solve the problems of unstable microstructure of beta-carotene emulsion, emulsion layering, and insufficient solubility of beta-carotene.

Inactive Publication Date: 2021-07-06
JIANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the solubility of the above-mentioned vegetable oils to β-carotene is not high enough, and the microstructure of the prepared β-carotene emulsion is unstable, resulting in obvious layering of the emulsion

Method used

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  • High-internal-phase beta-carotene nano-emulsion as well as preparation method and application thereof
  • High-internal-phase beta-carotene nano-emulsion as well as preparation method and application thereof
  • High-internal-phase beta-carotene nano-emulsion as well as preparation method and application thereof

Examples

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preparation example Construction

[0024] The invention provides a kind of preparation method of high internal phase β-carotene nanoemulsion, comprising the following steps:

[0025] (1) mixing the water-soluble protein carrier with water to obtain the water phase of the wall material;

[0026] (2) mixing β-carotene and medium-chain triglycerides to obtain a core material oil phase;

[0027] (3) Mix the water phase of the wall material and the oil phase of the core material to obtain a coarse emulsion; mix the coarse emulsion with a stabilizer, and perform high-pressure homogenization treatment, high-pressure micro-jet treatment and sterilization treatment in sequence to obtain a high-intensity emulsion phase β-carotene nanoemulsion;

[0028] The steps (1) and (2) are not in chronological order.

[0029] In the present invention, unless otherwise specified, all raw material components are commercially available products well known to those skilled in the art.

[0030] The invention mixes the water-soluble pr...

Embodiment 1

[0049] (1) Sodium caseinate is dissolved in deionized water to obtain a wall material aqueous phase with a sodium caseinate mass percentage of 2%;

[0050] (2) Place β-carotene in medium-chain triglycerides, stir magnetically at 37°C and 75rpm for 30min, then sonicate at 37°C and 85W for 10min, repeat the above magnetic stirring-sonication for 3 times, The core material oil phase with a mass percentage of β-carrot of 0.1% is obtained;

[0051] (3) The water phase of the wall material and the oil phase of the core material are mixed according to the volume ratio of 9:1 to obtain a coarse emulsion; gum arabic is added to the obtained coarse emulsion and mixed evenly, then high-pressure homogenization treatment is performed 6 times, and high-pressure micro-jet Treated 5 times, pasteurized at 65°C for 30min, cooled to 4°C and stored in a refrigerator at 4°C to obtain a high internal phase β-carotene nanoemulsion; wherein, the mass of gum arabic was casein 0.3% of the total mass o...

Embodiment 2～4

[0053] The high internal phase β-carotene nanoemulsion was prepared according to the method of Example 1, and the preparation conditions of Examples 2-4 are shown in Table 1.

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Abstract

The invention provides a high-internal-phase beta-carotene nano-emulsion as well as a preparation method and application thereof, and belongs to the technical field of carotene emulsions. The preparation method of the high-internal-phase beta-carotene nano-emulsion provided by the invention comprises the following steps of (1) mixing a water-soluble protein carrier with water to obtain a wall material water phase; (2) mixing beta-carotene and medium chain triglyceride to obtain a core material oil phase; and (3) mixing the wall material water phase and the core material oil phase to obtain a crude emulsion, mixing the crude emulsion with a stabilizer, and sequentially carrying out high-pressure homogenization treatment, high-pressure microjet treatment and sterilization treatment to obtain the high-internal-phase beta-carotene nano-emulsion. The high-internal-phase beta-carotene nano-emulsion prepared by the preparation method provided by the invention has the advantages of excellent microscopic stability, no layering and good storage stability, and the embedding rate and bioavailability of beta-carotene in the high-internal-phase beta-carotene nano-emulsion are high.

Description

technical field [0001] The invention relates to the technical field of beta-carotene embedding, in particular to a high internal phase beta-carotene nanoemulsion and its preparation method and application. Background technique [0002] As a fat-soluble antioxidant, β-carotene is also the most important plant-derived vitamin A source. It can be metabolized into retinoids in the body to participate in various life activities, and has the function of preventing chronic diseases. However, β-carotene has problems such as low solubility in water phase, poor stability in the gastrointestinal tract, low intestinal mucosal permeability and high metabolic clearance rate, which lead to difficulties in the effective absorption and utilization of β-carotene after oral intake. [0003] Carrier technology can improve the solubility, stability, permeability and bioavailability of β-carotene. Currently, the commonly used carriers for embedding β-carotene are vegetable oils such as peanut oi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A23P10/30A61K9/107A61K31/015A61K47/42A61K47/14A61K47/36
CPCA23L33/105A23P10/30A61K9/1075A61K31/015A61K47/42A61K47/14A61K47/36A23V2002/00
Inventor 贾晓燕张露涂宗财毛积华傅俏琴
Owner JIANGXI NORMAL UNIV
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