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Preparation method of sunscreen microspheres

A technology of microspheres and solutions, applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of large size, low sun protection performance, low performance, etc., to improve SPF value and PA value , improve sun protection comfort, and strong skin-friendliness

Active Publication Date: 2021-07-02
JIANGXI YONGTONG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008]That is to say, when zinc oxide is used as the main raw material of physical sunscreen in the prior art, the following technical problems are faced: (1) The size of ZnO is too large, resulting in low sunscreen performance (2) Small ZnO particles have good sun protection performance, but for physical sunscreens, they will cause blockage of human hair follicles, that is, too large ZnO particles are safe, but the performance is too low, and too small ZnO particles have high performance, but are safe sex is debatable

Method used

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  • Preparation method of sunscreen microspheres

Examples

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Effect test

Embodiment 1

[0041] A preparation method of sunscreen liquid microspheres, comprising the steps of:

[0042] 1) Add 72mg of initiator azobisisobutyronitrile, 2.5g of dispersant polyvinylpyrrolidone, and 0.79ml of crosslinking agent ethylene glycol dimethacrylate into a solvent of 95vol.% acetonitrile / 5vol.% toluene, fully Disperse to obtain a solution.

[0043] 2) Add 3g of methyl methacrylate and 1.5g of acrylamide to the solution obtained in step 1), slowly pass through N2 protection for 30min, and then rise to the reaction temperature of 85°C. After 4 hours of continuous reaction, the experiment is over, and the product is poured out. Vacuum filtration, tetrahydrofuran cleaning, 80 o C was washed with deionized water to obtain a white solid.

[0044] 3) Ultrasonic disperse 3g of the above white solid in 150ml of absolute ethanol, slowly add 75ml of 0.025M zinc acetate ethanol solution, let stand for 10min; then add 100ml of 0.05M zinc acetate ethanol solution, and continue stirring. ...

Embodiment 2

[0049] A preparation method of sunscreen liquid microspheres, comprising the steps of:

[0050] 1) Add 72mg of initiator azobisisobutyronitrile, 2.5g of dispersant polyvinylpyrrolidone, and 0.79ml of crosslinking agent ethylene glycol dimethacrylate into a solvent of 95vol.% acetonitrile / 5vol.% toluene, fully Disperse to obtain a solution.

[0051] 2) Add 3g of methyl methacrylate and 1.5g of acrylamide to the solution obtained in step 1), slowly pass through N2 protection for 30min, and then rise to the reaction temperature of 85°C. After 4 hours of continuous reaction, the experiment is over, and the product is poured out. Vacuum filtration, tetrahydrofuran cleaning, 80 o C was washed with deionized water to obtain a white solid.

[0052] 3) Ultrasonic disperse the above 4g of white solid in 150ml of absolute ethanol, slowly add 82.5ml of 0.03M zinc acetate ethanol solution, let it stand for 12.5min; then add 105ml of 0.06M zinc acetate ethanol solution, and continue stirr...

Embodiment 3

[0057] A preparation method of sunscreen liquid microspheres, comprising the steps of:

[0058] 1) Add 72mg of initiator azobisisobutyronitrile, 2.5g of dispersant polyvinylpyrrolidone, and 0.79ml of crosslinking agent ethylene glycol dimethacrylate into a solvent of 95vol.% acetonitrile / 5vol.% toluene, fully Disperse to obtain a solution.

[0059] 2) Add 3g of methyl methacrylate and 1.5g of acrylamide to the solution obtained in step 1), slowly pass through N2 protection for 30min, and then rise to the reaction temperature of 85°C. After 4 hours of continuous reaction, the experiment is over, and the product is poured out. Vacuum filtration, tetrahydrofuran cleaning, 80 o C was washed with deionized water to obtain a white solid.

[0060] 3) Ultrasonic disperse 5g of the above white solid in 150ml of absolute ethanol, slowly add 90ml of 0.05M zinc acetate ethanol solution, and let it stand for 15min; then add 110ml of 0.075M zinc acetate ethanol solution, and continue stir...

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Abstract

The invention provides a preparation method of sunscreen liquid microspheres. PMMA polymer microspheres containing- CH2-NH2 and -CO-NH2 groups are prepared, so excellent adsorption sites are provided for subsequent zinc oxide deposition, PMMA polymer microsphere cores and zinc oxide shells are convenient to form, and the SPF value and the PA value of sunscreen cosmetics can be remarkably increased through the inorganic core-shell structure.

Description

technical field [0001] The invention belongs to the field of cosmetics, in particular to a method for preparing sunscreen liquid microspheres, which belongs to the additive of sunscreen liquid. Background technique [0002] With the pollution of the environment and the destruction of the global atmosphere, more ultraviolet rays, high-energy blue light, and infrared rays irradiate the surface of the earth. All kinds of harmful light have caused certain damage to the human body. People are paying more and more attention to sun protection. In addition to traditional hard sun protection: sun umbrellas, sun protection clothing, sun hats, sun protection glasses, etc.; people's demand for sun protection and skin care products with broad-spectrum and high-efficiency sun protection is also increasing. At present, most of the sunscreens used in sunscreen products on the market are pure chemical sunscreens, pure physical sunscreens or a combination of chemical sunscreens and physical...

Claims

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Application Information

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IPC IPC(8): A61K8/02A61K8/27A61K8/81A61Q17/04
CPCA61K8/025A61K8/27A61K8/8152A61Q17/04A61K2800/621A61K2800/654A61K2800/41Y02A50/30
Inventor 郑小青
Owner JIANGXI YONGTONG TECH
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