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Anti-RNA virus drug target activity of compound solidago decurrens spray dry powder and its application

The technology of a spray and compound recipe is applied in the application field of compound solid goldenrod spray extract dry powder, the preparation of novel coronavirus pneumonia and antiviral drugs, and can solve the problem of no effective vaccine and the like

Active Publication Date: 2021-06-29
贵州中医药大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is currently no effective vaccine or specific treatment for this virus

Method used

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  • Anti-RNA virus drug target activity of compound solidago decurrens spray dry powder and its application
  • Anti-RNA virus drug target activity of compound solidago decurrens spray dry powder and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1: It is verified by experiments that the dry powder of the compound solidago spray extract extract, at 1 mg / mL, has an inhibitory rate of 55.6% to CathepsinL protease; the inhibitory rate to HIV-1 protease is IC 50 =0.38mg / mL, can be used for the preparation of treatment of new coronary pneumonia and antiviral drugs.

Embodiment 2

[0055] Embodiment 2: get the dry powder of the compound solidago spray extractum, make granules, capsules, tablets, injections, oral liquids, soft capsules, dropping pills and other pharmaceutically acceptable dosage forms.

Embodiment 3

[0056] Embodiment 3: Get the dry powder of the compound solidago japonica spray extract, add other antiviral raw materials for compounding, and make granules, capsules, tablets, injections, oral liquids, soft capsules, dropping pills, etc. Pharmaceutically acceptable dosage form.

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PUM

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Abstract

The invention discloses a novel application of compound solidago decurrens spray extract dry powder in pharmacy, and finds that when the concentration of the compound solidago decurrens spray extract dry powder is 1mg / mL, the inhibition rate of the compound solidago decurrens spray extract dry powder on a new coronavirus drug target Cathepsin L protease reaches 55.6%; when inhibition rate IC50 of the compound on HIV protease is 0.38 mg / mL, and the compound can be independently used or compounded with other drugs to be used for drugs for preventing and treating novel coronavirus pneumonia and antiviral drugs.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of dry powder of compound solidago spray extract extract in the preparation of novel coronavirus pneumonia and antiviral drugs. [0002] technical background [0003] The new coronavirus (SARS-CoV-2) belongs to the single-stranded RNA positive-strand enveloped β-coronavirus. After invading the human body through droplets, contact, and feces, it quickly attacks multiple organs such as the lungs, heart, kidneys, and intestines, causing Multiple organ failure, eventually leading to death. There is currently no effective vaccine or specific treatment for this virus. At present, more than 3 million cases of new coronary pneumonia have been infected worldwide, and new coronavirus infection has become one of the deadliest infectious diseases in the world, seriously endangering human health. [0004] The replication cycle of the new coronavirus (SARS-CoV-2) includes th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61K9/14A61P31/14A61P31/18
CPCA61K36/28A61K36/355A61K36/12A61K36/634A61K36/534A61K36/538A61K9/0073A61K9/14A61P31/14A61P31/18A61K2300/00Y02A50/30
Inventor 危英李星周英夏文马超美杨欣
Owner 贵州中医药大学
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