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Model construction method for predicting prognosis risk of early-stage colon cancer patient

A construction method and colon cancer technology, applied in the biological field, can solve the problems of single gene number, low accuracy and poor pertinence, and achieve the effect of simple gene detection method, high accuracy and easy implementation.

Pending Publication Date: 2021-06-25
NANJING FIRST HOSPITAL
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Problems solved by technology

[0002] Colon cancer is one of the most common malignant tumors in the world, and its incidence and mortality rate are among the top three among all malignant tumors; the overall survival rate of colon cancer patients depends on the TNM stage of the tumor, and generally advanced patients are more advanced than early patients. The prognosis is poor. According to the report of the American Joint Committee on Cancer (AJCC), the 5-year survival rates of patients with stage I, II, III, and IV colon cancer are 93.2%, 82.5%, 59.5%, and 8.1%, respectively; Due to the very poor prognosis of some early (stage I / II) colon cancer patients, most of the tumor markers commonly used in clinical practice are aimed at the early diagnosis of colon cancer, and the markers for the prognosis of colon cancer patients either generally include all TNM Staged patients are poorly targeted, or the number of predicted genes is single, and the accuracy is low

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  • Model construction method for predicting prognosis risk of early-stage colon cancer patient
  • Model construction method for predicting prognosis risk of early-stage colon cancer patient
  • Model construction method for predicting prognosis risk of early-stage colon cancer patient

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[0023] The directional terms mentioned in the present invention, such as "up", "down", "front", "back", "left", "right", "inside", "outside", "side", etc., are only appended The directions in the figure are only used to explain and illustrate the present invention, not to limit the protection scope of the present invention.

[0024] see Figure 1 to Figure 5 , the present invention constructs a kind of model that predicts the prognostic risk of early colon cancer patient, and its construction method comprises the following steps:

[0025] Step 1: Obtain a tumor tissue sample from the patient through surgery.

[0026] First, formulate patient selection criteria, select patients according to the criteria, surgically resect the tumor tissue of the patient, and immediately store it in liquid nitrogen after the pathological diagnosis of stage I or II colon cancer until it is taken out when used, such as figure 1 As shown, according to the postoperative survival time of patients, ...

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Abstract

The invention relates to a model construction method for predicting the prognosis risk of an early-stage colon cancer patient. The model construction method specifically comprises the following steps: firstly, obtaining a tumor tissue specimen of the patient through an operation; detecting the expression of the gene content in a tumor tissue sample of a patient by using difference analysis; then screening genes for constructing a risk model by using single-factor Cox regression analysis and LASSO regression analysis, and establishing a calculation formula of the risk model; finally, using Kaplan-Meier prognosis analysis and ROC analysis to verify the accuracy of the prognosis risk model for prognosis prediction in early-stage colon cancer patients. The method can better guide clinical design of a more targeted treatment scheme for a patient with poor early colon cancer prognosis, and realizes precise medical treatment; The number of genes for constructing the prediction model is large, the influence caused by tumor heterogeneity can be reduced to the maximum extent, and the accuracy is high; The gene detection method is simple and easy to implement.

Description

【Technical field】 [0001] The invention relates to the field of biotechnology, in particular to a method for constructing a model for predicting the prognosis risk of patients with early colon cancer. 【Background technique】 [0002] Colon cancer is one of the most common malignant tumors in the world, and its incidence and mortality rate are among the top three among all malignant tumors; the overall survival rate of colon cancer patients depends on the TNM stage of the tumor, and generally advanced patients are more advanced than early patients. The prognosis is poor. According to the report of the American Joint Committee on Cancer (AJCC), the 5-year survival rates of patients with stage I, II, III, and IV colon cancer are 93.2%, 82.5%, 59.5%, and 8.1% respectively; Due to the very poor prognosis of some early (stage I / II) colon cancer patients, most of the tumor markers commonly used in clinical practice are aimed at the early diagnosis of colon cancer, and the markers for...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/30G16H50/20C12Q1/6886
CPCG16H50/30G16H50/20C12Q1/6886C12Q2600/118C12Q2600/158
Inventor 王书奎刘翔翔何帮顺秦健潘玉琴孙慧玲许桃
Owner NANJING FIRST HOSPITAL
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