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Application of CD155 in diagnosis and treatment of cervical cancer

A technology for cervical cancer and cervical cancer cells, applied in the application field of CD155 in the diagnosis and treatment of cervical cancer, can solve problems such as unclear molecular mechanism

Pending Publication Date: 2021-06-25
SHANDONG UNIV QILU HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the molecular mechanism of CD155 in the development of cervical cancer is still unclear

Method used

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  • Application of CD155 in diagnosis and treatment of cervical cancer
  • Application of CD155 in diagnosis and treatment of cervical cancer
  • Application of CD155 in diagnosis and treatment of cervical cancer

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Experimental program
Comparison scheme
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Embodiment

[0074] 1. Materials and methods

[0075] 1.1 Human tissue samples

[0076] Seventy serum samples were collected, including 31 cases of cervical cancer, 21 cases of HSIL and 18 cases of normal cervix. In addition, 100 paraffin samples were collected, including 66 cervical cancers, 16 HSIL and 18 normal cervixes. All patients were clinically staged according to the FIGO guidelines. The clinical data come from the medical record management system of Qilu Hospital. The Ethics Committee of Qilu Hospital approved this study.

[0077] 1.2 Immunohistochemistry

[0078] Immunohistochemistry was carried out according to the immunohistochemistry detection kit (Zhongshan Jinqiao SP-9001). Four micron thick paraffin sections were deparaffinized and incubated with CD155 antibody overnight at 4°C. Incubate sections with biotinylated goat anti-rabbit IgG secondary antibody at 37°C for 10 min. Streptavidin peroxidase was incubated with sections at 37 °C for 15 min before DAB staining. Se...

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Abstract

The invention relates to the technical field of crude drugs and molecular biology, in particular to application of CD155 in diagnosis and treatment of cervical cancer. It is found for the first time that the expression quantity of CD155 is related to multiple molecular pathological indexes of cervical cancer, AKT / mTOR activity and an NF-kappa B pathway can be inhibited by silencing CD155, autophagy and apoptosis can be activated, and malignant progression of cervical cancer can be effectively inhibited by specifically knocking out CD155. In addition, silencing of CD155 inhibits the progress of the cell cycle by down-regulating CyclinD1 and up-regulating P27 KIP1. The discovery shows that the CD155 can be used as a molecular biomarker for diagnosing and treating cervical cancer, and can also be potentially used as a valuable treatment target for cervical cancer patients, so that the CD155 has good practical application value.

Description

technical field [0001] The invention relates to the technical fields of crude drug medicine and molecular biology, in particular to an application of CD155 in the diagnosis and treatment of cervical cancer. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Cervical cancer is a malignant tumor with the fourth highest morbidity and mortality among women, and has become an important disease that threatens women's health. According to reports, the incidence of cervical cancer among women is on the rise year by year. In 2018, there were more than 569,000 new cases of cervical cancer and 311,000 deaths. Cervical cancer is the only cancer with a clear etiology among all cancers, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/574A61K45/06A61P35/00A61P15/00
CPCG01N33/6893G01N33/57484G01N33/57442A61K45/06A61P35/00A61P15/00G01N2333/70596
Inventor 张友忠刘露孟丽华钱秋红刘洪丽韩赛李艺孙雨张俊华尤学武郭玲宇刘晓丽
Owner SHANDONG UNIV QILU HOSPITAL
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