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FBA oral flora functional group obtained based on microbial functional group mining method

A technology of functional groups and flora, applied in the fields of bioinformatics and medical health

Pending Publication Date: 2021-06-22
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the field of microbial ecology, there is still a lack of effective analytical methods to find out functional groups from bacterial flora.

Method used

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  • FBA oral flora functional group obtained based on microbial functional group mining method
  • FBA oral flora functional group obtained based on microbial functional group mining method
  • FBA oral flora functional group obtained based on microbial functional group mining method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Application of analytical technology for mining microbial functional groups in healthy human oral flora

[0019] Data Sources

[0020] The present invention adopts the 16S rRNA data of oral microbial flora of healthy people first published by Zaura et al. in 2009. The data were collected from three healthy adult males. Each individual collected 9-10 oral parts, including the tooth surface of upper incisors and upper molars, buccal mucosa, hard palate and tongue surface, and saliva. Finally, a total of 29 oral samples were obtained. Bacterial samples. Through 16srRNA amplicon sequencing and subsequent bioinformatics analysis, a microbial taxonomic unit (operational taxonomic unit, OTU) with a similarity of 97% was obtained. In this patent, each OTU represents a species, named as "species (phylum, class, order, family, genus) name_species number".

[0021] Build an oral flora interaction network:

[0022] The total number of reads for each OTU was taken as ...

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Abstract

The invention relates to the field of biological information technology and medical health, and discloses a concept, thought and method for mining a community functional group based on the network analysis technology, and an FBA functional group found from a healthy human oral flora. The functional group is mainly composed of bacteria of the phylum F, the phylum B and the phylum A of actinobacteria, the whole functional group is of a structure that the phylum F and the phylum B synergistically inhibit the phylum A, and the functional group is generally a module with the most species number and the highest density in a healthy oral cavity network. Specifically, the functional group is composed of two sub-functional groups (Sub-Guld), wherein one of the sub-functional groups is mainly composed of F and B mycophylum bacteria, and the other one of the sub-functional groups is mainly A mycophylum bacteria. Species in the two sub-functional groups are in a synergistic relationship, but the two sub-functional groups are in a complete antagonistic competition relationship. The FBA functional group can effectively reflect the stability of the environment in the oral cavity, and a biological foundation is laid for oral health and oral disease healing condition monitoring.

Description

technical field [0001] The present invention relates to the fields of biological information technology and medical health, and in particular to the concept, idea and method of mining community "Functional Guild" based on network analysis technology, and a FBA function found from the healthy oral flora of human body group. Background technique [0002] Functional Guild refers to a group of species in which members of the species either exploit the same resources or develop different resources in some related way. Different from the concept of ecological niche, functional groups are mainly defined according to the geographical location, attributes or activities of species members. Species within a functional group can occupy different or even dissimilar ecological niches. Functional group is the implementer of some special functions in the ecosystem, which is closely related to the stability of the ecosystem. Through the functional group, it can effectively detect the chan...

Claims

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Application Information

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IPC IPC(8): G16H50/30G16B30/00A61B10/00A61B5/00
CPCG16H50/30G16B30/00A61B10/0051A61B5/48
Inventor 马占山李文迪
Owner KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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