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Composite electrospun membrane for promoting tendon-bone healing as well as preparation method and application of composite electrospun membrane

An electrospun film and electrospinning technology, which is applied in the field of biomedical materials, can solve the problems of lack of fusion of grafts and bone tunnels, and achieve the effect of improving tendon-bone healing, being highly targeted, and promoting tendon-bone healing

Active Publication Date: 2021-06-22
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there is still a lack of implant materials and technical means that can effectively promote the fusion between the graft and the bone tunnel during the clinical reconstruction of the anterior cruciate ligament.

Method used

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  • Composite electrospun membrane for promoting tendon-bone healing as well as preparation method and application of composite electrospun membrane
  • Composite electrospun membrane for promoting tendon-bone healing as well as preparation method and application of composite electrospun membrane
  • Composite electrospun membrane for promoting tendon-bone healing as well as preparation method and application of composite electrospun membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Example 1 The present invention has a degradable polymer composite electrospun membrane with uniform ceramic content

[0056] (1) Weigh an appropriate amount of polylactic acid (PLA) and add hexafluoroisopropanol solution, and then uniformly stir at 37°C for 1 hour to form a uniform solution with a concentration of 18%;

[0057] (2) Add hydroxyapatite powder with a particle size of 100 nm to the above polymer solution in an amount such that the mass fraction of hydroxyapatite in the finally obtained electrospun membrane is 10%, and stir at 37° C. for 1 h.

[0058] (3) Put the hydroxyapatite / PLA spinning solution obtained in step (2) into the propulsion pump of the spinning machine, the drum speed is 500r / min, the syringe pump propulsion speed is 2.4ml / h, the temperature is 25°C, and the humidity is 65°C. %, the receiving distance is 15cm, and the spinning starts under the condition of voltage 12KV. After the spinning is completed, the primary product of electrospun mem...

Embodiment 2

[0060] Example 2 The present invention has a degradable polymer composite electrospun membrane with uniform ceramic content

[0061] (1) Weigh an appropriate amount of polylactic acid (PLA) and add hexafluoroisopropanol solution, and then uniformly stir at 37°C for 1 hour to form a uniform solution with a concentration of 22%;

[0062] (2) Add hydroxyapatite powder with a particle size of 100 nm to the above polymer solution in an amount such that the mass fraction of hydroxyapatite in the finally obtained electrospun membrane is 45%, and stir at 37° C. for 1 h.

[0063] (3) Put the hydroxyapatite / PLA spinning solution obtained in step (2) into the propulsion pump of the spinning machine, the drum speed is 600r / min, the syringe pump propulsion speed is 3mL / h, the temperature is 25°C, and the humidity is 60%. , the receiving distance is 13cm, and the spinning is started under the condition of voltage 14KV. After the spinning is completed, the primary product of electrospun mem...

Embodiment 3

[0065] Embodiment 3 The present invention has degradable polymer electrospun membrane

[0066] (1) Weigh an appropriate amount of PLCL and add hexafluoroisopropanol solution, and then uniformly stir for 1 hour at 37°C to form a uniform solution with a concentration of 26%;

[0067] (2) Put the PLCL spinning solution obtained in step (1) into the propulsion pump of the spinning machine, the drum speed is 500r / min, the syringe pump propulsion speed is 2.4mL / h, the temperature is 25°C, the humidity is 65%, and the receiving distance is 15cm , Spinning starts under the condition of a voltage of 12KV. After the spinning is completed, the primary electrospun membrane with a certain width is received on the drum tinfoil.

[0068] (3) Dry the primary electrospun membrane obtained in step (2) in a vacuum oven at 37°C for 24 hours to obtain a PLCL electrospun membrane.

[0069] (4) The SEM image of the PLCL electrospun membrane obtained in step (3) figure 1 (a) shown.

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Abstract

The invention discloses a composite electrospinning membrane for promoting tendon-bone healing as well as a preparation method and application of the composite electrospinning membrane. A matrix of the composite electrospinning membrane is a degradable high polymer material, and calcium phosphate ceramic particles are uniformly dispersed or dispersed in the matrix in a concentration gradient manner. The composite electrospinning membrane can select a proper material system and load concentration according to specific conditions of ligament grafts and ligament repair and reconstruction operations, meets different requirements of tendon-bone healing application in ligament repair and reconstruction, can be trimmed according to the sizes of articular cavities and bone tunnels of patients, coats the surfaces of autologous or artificial ligament grafts, constructs ligament grafts with different section characteristics of bone tunnels and articular cavities, and achieves personalized precise treatment.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a composite electrospun membrane for promoting tendon-bone healing and its preparation method and application. Background technique [0002] Common tendon and ligament injuries include anterior cruciate ligament (ACL), Achilles tendon (Achilles tendon, AT), rotator cuff (rotator cuff, RC) and other injuries. ACL is an important forward stabilizing structure of the knee joint. After breaking, it can cause obvious instability of the knee joint and seriously affect the function of the knee joint. If it is not treated in time, the joint will be sprained repeatedly, which will easily cause damage to important structures such as articular cartilage and meniscus. , leading to premature aging of the joints and the occurrence of osteoarthritis. [0003] Tendon and ligament injuries usually involve the tendon-bone junction, and the healing time and healing effect of the tendon-bone jun...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/42A61L27/46A61L27/58D01F6/92D01F1/10D04H1/728D01D5/00
CPCA61L27/46A61L27/425A61L27/58D01F6/92D01F1/10D04H1/728D01D5/003D01D5/0092A61L2430/10
Inventor 林海苏金磊江青松王境徐扬刘展鸿朱向东张凯张兴栋
Owner SICHUAN UNIV
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