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Marker used for predicting isocitrate dehydrogenase 1 gene wild-type glioma prognosis and anti-PD1 treatment curative effect, and application of marker

A wild-type technology of isocitrate dehydrogenase, applied in the field of biomedicine, to achieve the effect of great application prospects

Active Publication Date: 2021-06-18
SUN YAT SEN UNIV CANCER CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on markers for predicting the prognosis of isocitrate dehydrogenase 1 gene wild-type glioma and the efficacy of anti-PD1 therapy.

Method used

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  • Marker used for predicting isocitrate dehydrogenase 1 gene wild-type glioma prognosis and anti-PD1 treatment curative effect, and application of marker
  • Marker used for predicting isocitrate dehydrogenase 1 gene wild-type glioma prognosis and anti-PD1 treatment curative effect, and application of marker
  • Marker used for predicting isocitrate dehydrogenase 1 gene wild-type glioma prognosis and anti-PD1 treatment curative effect, and application of marker

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Experimental program
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Effect test

Embodiment 1

[0034] 1. Method

[0035] 1. Data extraction

[0036] Use the https: / / xenabrowser.net website to download the RNA sequencing expression profiles and clinical data of 231 cases of isocitrate dehydrogenase 1 gene wild-type gliomas in the TCGA Cancer Genome Atlas as a training set, and download the Chinese Glioma Genome Atlas ( The RNA-seq gene expression data of CGGA) and the gene expression chip (microarray) data and clinical data of the Gene Expression Omnibus (GEO) data set numbered GSE16011 were used as validation sets.

[0037] 2. Transcriptome and genome data processing

[0038] Gene expression was calculated by TPM and normalized by 11 internal reference genes (C1orf43, CHMP2A, EMC7, GPI, PSMB2, PSMB4, RAB7A, REEP5, SNRPD3, VCP, VPS29). Somatic gene mutations and gene copy number changes in glioma tissues were calculated using the TCGA OncoGrid algorithm. The calculation of gene mutation rate, aneuploidy score and neoantigen in glioma tissue was calculated by the formu...

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Abstract

The invention discloses a marker used for predicting isocitrate dehydrogenase 1 gene wild-type glioma prognosis and an anti-PD1 treatment curative effect, and application of the marker. The marker consists of BST1, SPP1, PTX3 and ABCC3. The marker composition which is provided by the invention and consists of four genes, including the BST1, the SPP1, the PTX3 and the ABCC3 can reflect the immune microenvironment status of the isocitrate dehydrogenase 1 gene wild-type glioma, more accurately predicts the prognosis and anti-PD1 treatment curative effect of an isocitrate dehydrogenase 1 gene wild-type glioma patient, more favorably guides clinical medicine utilization, is superior to tumor mutation load (TMB) and an expression level of PD-L1 by aiming at the prediction efficacy of the anti-PD1 treatment curative effect, and has a huge application prospect.

Description

technical field [0001] The present invention relates to the field of biomedical technology, and more specifically, to a marker for predicting the prognosis of isocitrate dehydrogenase 1 gene wild-type glioma and the curative effect of anti-PD1 therapy and its application. Background technique [0002] Glioma is the most common primary intracranial tumor in adults. Isocitrate dehydrogenase 1 gene wild-type gliomas have a poor prognosis. The primary glioblastoma of WHO grade IV is all wild-type isocitrate dehydrogenase 1 gene. Even after surgery, radiotherapy and chemotherapy, the median survival time is only 20.5 months. The prognosis of low-grade glioma with wild-type isocitrate dehydrogenase 1 gene is significantly worse than that of mutant low-grade glioma, and is closer to the prognosis of glioblastoma. Therefore, finding effective treatment methods and predicting prognosis are the key points in the treatment of isocitrate dehydrogenase 1 gene wild-type glioma. However...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886G16B25/00G16B40/30
CPCC12Q1/6886G16B25/00G16B40/30C12Q2600/118C12Q2600/106C12Q2600/158
Inventor 赛克李德培蒋小兵张沛雨陈忠平牟永告
Owner SUN YAT SEN UNIV CANCER CENT
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