Anti-drunkenness, hangover-alleviating and liver-protecting composition and preparation method and application thereof
A technology for relieving alcohol and protecting the liver and a composition, which is applied in the directions of application, drug combination, and pharmaceutical formulation, can solve the problems such as not making substantial progress, and achieve the effects of delaying the absorption rate of ethanol into the blood, increasing the content, and matching rationally.
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[0034] The present invention also provides a preparation method of the above anti-drunk, anti-alcohol and liver-protecting composition, comprising the following steps:
[0035] A) dissolving pectin and kudzu root extract in deionized water to obtain a mixed aqueous solution;
[0036] B) preparing calcium alginate gel microspheres after dispersing curcumin, citrus flavonoids, and total flavonoids of Hovenia dulcis in sodium alginate solution;
[0037] C) mixing the mixed aqueous solution with calcium alginate gel microspheres to obtain an anti-drunk, anti-alcoholic and liver-protecting composition.
[0038] The invention dissolves pectin and kudzu root extract in deionized water to obtain a mixed aqueous solution. Specifically, pectin and kudzu root extract are dissolved in deionized water, and insoluble impurities are removed by microfiltration.
[0039] The invention prepares calcium alginate gel microspheres after dispersing curcumin, citrus flavonoids and total flavonoids...
Embodiment 1
[0049] 1. A new anti-drunk, anti-drunk and liver-protecting formula provided in this example contains the following components:
[0050] (1) The citrus pectin content is 3% (w / w), the molecular weight is 240kD, and the degree of esterification is 20%;
[0051] (2) Pueraria root extract 1.0% (w / w);
[0052] (3) Curcumin 0.5% (w / w);
[0053] (4) Citrus flavonoids 0.4% (w / w);
[0054] (5) Total flavonoids of Hovenia dulcis 0.35% (w / w);
[0055] The balance is water.
[0056] 2. Preparation method:
[0057] (1) Pectin and kudzu root extract are dissolved in deionized water, and insoluble impurities are removed by microfiltration;
[0058] (2) Curcumin, citrus flavonoids, Hovenia dulcis Fructus total flavonoids are dispersed in a sodium alginate solution with a mass concentration of 1.5wt%, and then the mixed solution is dropped into a calcium chloride solution with a mass concentration of 1.1wt% to form alginic acid Calcium gel microspheres;
[0059] (3) Clean the calcium a...
Embodiment 2
[0081] Example 2 Animal experiments on anti-alcoholic and liver-protecting products:
[0082] 1. Experimental method:
[0083] (1) Experimental animals and groups
[0084] 100 C57BL / 6 mice, male, weighing 15-30g, were adaptively fed for 7 days, and were randomly divided into a blank group (10 mice), a model group (10 mice), and a Neptune Jinzun group (an anti-alcoholic drug sold on the market). , 10), embodiment 1 combined formula group (10), comparative example 1 no pectin combined formula group (10), comparative example 2 pectin group (10), comparative example 3 kudzu root extract group (10 only), comparative example 4 curcumin group: (10), comparative example 5 citrus flavonoids group (10), comparative example 6 hovenia dulcis total flavonoids group (10).
[0085] (2) Modeling and administration
[0086] 1) Modeling method: 90 rats in all groups except the blank group, fasted for 12 hours before the experiment, fed with 0.15mL / 10g body weight with Fuyu Laojiao at 38°.
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