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Application of panax notoginseng saponins in preparation of medicine for treating colitis-related colon cancer

A technology of Panax notoginseng saponins and therapeutic drugs, applied in the field of medicine, can solve the problems of difficult to identify malignant hyperplasia and early canceration phenomenon and the like

Inactive Publication Date: 2021-06-18
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical symptoms of CAC patients are similar to those of IBD patients, and it is difficult to identify malignant hyperplasia and early canceration by current colonoscopy, resulting in most of the diagnosed CAC patients being in the middle and late stages

Method used

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  • Application of panax notoginseng saponins in preparation of medicine for treating colitis-related colon cancer
  • Application of panax notoginseng saponins in preparation of medicine for treating colitis-related colon cancer
  • Application of panax notoginseng saponins in preparation of medicine for treating colitis-related colon cancer

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Embodiment Construction

[0019] Below in conjunction with specific embodiment, further illustrate the present invention. The following examples are only used to illustrate the present invention, without any limitation to the protection scope of the present invention.

[0020] (1) Establishment of mouse AOM-DSS (A / D) colitis cancer model: Select 50 healthy C57 mice or transgenic mice, weighing 18-20g, male and female, and divide them into 5 groups randomly, 10 mice in each group . After 1 week of adaptive feeding, each mouse was injected intraperitoneally with 10 mg / kg of azoxymethane (AOM). After 7 days of normal diet and drinking water, it was given drinking water containing 2.5% dextran sodium sulfate (DSS). After 7 days, it was changed to Normal diet and drinking water for 14 days, so as a cycle. Prophylactic administration of 75 (low dose group, L) and 150 (high dose group, H) mg / kg PNS was started one week in advance. Diarrhea and gross bloody stools were observed every day during the modeling...

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Abstract

The invention discloses application of panax notoginseng saponins in preparation of a medicine for treating or preventing colitis-related colon cancer. The invention finds that the panax notoginseng saponins have obvious chemical prevention and treatment effects on the colitis-related colon cancer; and as an active component of Xuesaitong, the safety and low toxicity of the panax notoginseng saponins are fully accepted, and a new adjuvant medication scheme is provided for clinically preventing and treating colon cancer.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of Panax notoginseng saponins in the preparation of medicines for treating colitis-associated colon cancer. Background technique [0002] The dynamic change and remodeling of the inflammatory microenvironment during inflammatory-cancer transformation promotes the malignant proliferation and migration of tumor cells, and induces carcinogenesis reprogramming. Colitis-associated colon cancer (CAC) is a typical inflammation-related tumor, and the occurrence of inflammatory bowel disease (Inflammatory bowel disease, IBD) is a clear high-risk factor for CAC. The continuous accumulation of inflammatory factors and reactive oxygen species that cause DNA damage makes the probability of CAC in IBD patients significantly higher than that of the general population, and the cancer rate increases year by year with the prolongation of the disease course and is positively correlated with ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P35/00
CPCA61K36/258A61P35/00
Inventor 王亚菁李雪明朱磊袁丁艺严方
Owner CHINA PHARM UNIV
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