Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Shape memory chitosan hydrogel and preparation method thereof

A technology of chitosan and chitosan fiber, which is applied in the field of material chemistry and natural polymers, can solve the problems of limited application, poor mechanical properties of chitosan-based hydrogel, etc., to improve mechanical properties and facilitate large-scale preparation , the effect of reducing usage

Active Publication Date: 2021-06-11
WUHAN UNIV
View PDF10 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, chitosan-based hydrogels have poor mechanical properties, and there are still some limitations in mechanical strength and toughness, which greatly limit their applications in various fields.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Shape memory chitosan hydrogel and preparation method thereof
  • Shape memory chitosan hydrogel and preparation method thereof
  • Shape memory chitosan hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Add 0.2g of chitosan to a beaker containing 99.8g of deionized water, add 0.2ml of glacial acetic acid dropwise during magnetic stirring, and continue stirring for 2 hours to obtain a chitosan solution;

[0039] (2) Preparation of chitosan fiber bundle suspension with good stability. Use a homogenizer to stir the chitosan solution in step (1) at a speed of 2000 rpm, while adding a certain volume of Na 2 CO 3 Solution (0.5mol / L) makes pH reach 7; Stir 5min time to obtain stable white milky chitosan fiber bundle suspension;

[0040] (3) Add glutaraldehyde with a concentration of 20% to the white milky chitosan fiber bundle suspension described in step (2) (the mass ratio of glutaraldehyde to chitosan is 1:1), mix well, Obtain cross-linked chitosan fiber bundle suspension;

[0041] (4) Use a centrifuge to concentrate the suspension obtained in step (3) at a speed of 500 rpm, remove the supernatant to obtain a concentrated suspension of cross-linked chitosan fiber bu...

Embodiment 2

[0045] (1) Add 4g of chitosan to a beaker containing 96g of deionized water, add 1.5ml of concentrated hydrochloric acid dropwise during magnetic stirring, and continue stirring for 16 hours to obtain a chitosan solution;

[0046] (2) Preparation of chitosan fiber bundle suspension with good stability. Use a homogenizer to stir the chitosan solution in step (1) at a speed of 18000rpm, while adding a certain volume of K(OH) 2 Solution (0.5mol / L) makes pH reach 12; Stir 6min to obtain stable white milky chitosan fiber bundle suspension;

[0047] (3) Centrifuge and concentrate the white milky chitosan fiber bundle suspension obtained in step (2) at a speed of 10,000 rpm, remove the supernatant to obtain a concentrated chitosan fiber bundle suspension, and inject it into 6 holes In the polytetrafluoroethylene plate mold, the shape of each hole of the mold is the shape of the hydrogel to be prepared, and the amount added to each hole is 6ml.

[0048] (4) Place the 6-hole polytetr...

Embodiment 3

[0051] (1) Add 1g of chitosan to a beaker containing 99g of deionized water, add 0.45ml of glacial acetic acid dropwise during magnetic stirring, and continue stirring for 4 hours to obtain a chitosan solution;

[0052] (2) Preparation of chitosan fiber bundle suspension with good stability. Use a homogenizer to stir the chitosan solution in step (1) at a speed of 5000rpm, and add a certain volume of NaOH solution (1mol / L) dropwise to make the pH reach 14; stir for 8min to obtain stable white milky chitosan fibers beam suspension;

[0053] (3) Add epichlorohydrin (the mass ratio of epichlorohydrin to chitosan is 3:1) to the white milky chitosan fiber bundle suspension described in step (2), and mix evenly to obtain cross-linked Chitosan fiber bundle suspension;

[0054] (4) Centrifuge and concentrate the cross-linked chitosan fiber bundle suspension obtained in step (3) at a speed of 3000 rpm, remove the supernatant to obtain a concentrated cross-linked chitosan fiber bundle...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
quality scoreaaaaaaaaaa
Login to View More

Abstract

The invention discloses shape memory chitosan hydrogel and a preparation method thereof. The preparation method comprises the steps: firstly, dissolving chitosan under an acidic condition to obtain a chitosan solution; stirring the chitosan solution at a high speed by using a homogenizer, deprotonating chitosan by using alkali liquor to convert the chitosan into a gel state, completing preliminary assembly, and stirring to obtain a stable white milky chitosan fiber bundle suspension; adding a cross-linking agent while stirring to obtain a cross-linked chitosan fiber bundle suspension; concentrating to obtain concentrated turbid liquid, injecting the concentrated turbid liquid into a mold with a required shape, and standing for a period of time to enable the chitosan and a cross-linking agent to fully react; freezing in a refrigerator to obtain a frozen body, and performing ice crystal growth under a low-temperature condition for secondary assembly; and unfreezing the frozen body to obtain the chitosan hydrogel with the shape memory function. The chitosan hydrogel prepared by the invention has the advantages of good mechanical property, good water absorption performance, simple preparation process and easiness in large-scale preparation.

Description

technical field [0001] The invention belongs to the technical field of material chemistry and natural polymers, and relates to a gel material, in particular to a shape memory chitosan hydrogel and a preparation method thereof. Background technique [0002] Chitosan is a natural polymer with abundant resources and wide sources in nature. It has excellent properties such as renewability, biodegradability, biocompatibility, antibacterial property, multifunctional group reactivity, and promotion of wound healing. . Hydrogel is a kind of flexible substance with a three-dimensional network structure and rich water content. It has excellent water absorption and water retention and gel stability, and can be used as a good matrix, carrier or skeleton for functional soft materials. Based on the above advantages, gels, scaffolds and sponges developed based on chitosan are widely used in adsorption recovery, oil-water separation, and many biomedical fields, including medical hemostatic...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/08
CPCC08J3/075C08J2305/08
Inventor 施晓文齐鲁荷邓红兵杜予民
Owner WUHAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com