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Application of a compound in the preparation of medicines for treating or preventing viral hepatitis

A compound and drug technology, applied in antiviral agents, pharmaceutical formulations, organic active ingredients, etc., to achieve excellent clinical safety, good druggability, and the effect of curing hepatitis B

Active Publication Date: 2021-12-21
HOLY HAID LAB CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The point is that there is still no drug that can completely clear the virus and achieve a functional cure for hepatitis B

Method used

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  • Application of a compound in the preparation of medicines for treating or preventing viral hepatitis
  • Application of a compound in the preparation of medicines for treating or preventing viral hepatitis
  • Application of a compound in the preparation of medicines for treating or preventing viral hepatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Embodiment 1-application of HepG2-NTCP cells to evaluate the in vitro anti-HBV activity of the compound of formula 1

[0086] Compound preparation method is as follows:

[0087] Take the preparation of a stock solution with a concentration of 20mM as an example, the volume of the solvent DMSO (μl) = sample mass (mg) × purity ÷ molecular weight ÷ 20 × 10 6

[0088] Control compounds include ETV (lot number: P1214012; 99.0% purity), purchased from Shanghai Titan Technology Co., Ltd. The positive control compound RG7834 (batch number: ET25747-14-P1; 99.5% purity) was purchased from Shanghai WuXi Kangde New Drug Development Co., Ltd.

[0089] The stock solutions of the above reference compounds were all at a concentration of 20 mM and stored at -20°C.

[0090] Table 1. Major Reagents and Cell Viruses

[0091]

[0092]

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PUM

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Abstract

The invention provides the application of a compound in the preparation of medicine for treating or preventing viral hepatitis. The compound is a compound of formula 1 or a pharmaceutically acceptable salt thereof. Preferably, the viral hepatitis is hepatitis B. The present invention also provides a pharmaceutical composition for treating or preventing viral hepatitis, which comprises a compound of formula 1 or a pharmaceutically acceptable salt thereof, optionally one or more additional therapeutic agents or preventive agents, and pharmaceutically acceptable carrier.

Description

technical field [0001] The invention relates to the technical field of antiviral drugs, in particular to a pharmaceutical composition for treating or preventing viral hepatitis and its application. Background technique [0002] Human hepatitis B virus (HBV) infection is an important public health problem worldwide. After acute hepatitis B virus infection, about 8% still develop into chronic hepatitis B infection, and persistent HBV infection will lead to liver cirrhosis and even liver cancer. my country is a big country with hepatitis B, and there are nearly 130 million hepatitis B virus carriers, accounting for about 9% of the total population. Although the new hepatitis B infection rate has been effectively controlled with the widespread popularization of hepatitis B vaccine, the population base of hepatitis B virus carriers is large, and the prevention and treatment of hepatitis B has become the top priority of public health problems in my country. Hepatitis B transmiss...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/415A61K45/06A61P31/20
CPCA61K31/415A61K45/06A61P31/20
Inventor 李瑛颖陈明键仇思念
Owner HOLY HAID LAB CORP
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