Sensor based on bipolar electrode structure and method for non-enzyme detection of glucose

Abstract

The invention discloses a sensor based on a bipolar electrode structure and a method for non-enzyme detection of glucose. The sensor comprises a photosensitive resin 3D printing electrochemical cell, wherein two parallel Pt plate electrodes are arranged on the two sides of the electrochemical cell in a wall attaching mode, one Pt plate electrode serves as a cathode driving electrode to separate out hydrogen, and Pd is electroplated outside the Pt plate electrode to absorb hydrogen; two gold wire electrodes parallel to the Pt plate electrodes are arranged in the middle of the Pt plate electrode. After voltage is applied to the driving electrode, a hydrogen evolution reaction occurs on the cathode of the driving electrode, a large number of hydroxyl ions are generated in a solution near the Pt plate electrode, and under the action of an electric field formed between parallel Pt, the hydroxyl ions are directionally migrated and diffused from the cathode region to the anode region of the driving electrode, and then an alkaline environment is formed around the bipolar electrode made of gold, so that the aim of catalyzing a glucose non-enzymatic oxidation reaction is fulfilled. Therefore, enzyme-free glucose detection can be completed only by a single device.

Description

technical field [0001] The invention relates to a sensor and a use method, in particular to a sensor based on a bipolar electrode structure and a method for non-enzyme detection of glucose. Background technique [0002] The application of glucose sensors in blood, urine, sweat, saliva has been widely reported, most of these applications are for non-invasive screening. With the increase in the number of patients with various types of diabetes, the importance of early screening and prevention has become increasingly prominent. Therefore, more and more research topics have begun to focus on the application of non-invasive wearable sensors for long-term sustainable use of glucose level monitoring. However, most of the current detection methods are improved based on enzyme-catalyzed methods (such as glucose oxidase and glucose dehydrogenase). This principle is usually used on disposable glucose test strips, and the corresponding The instrument reads the glucose concentration. T...

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Problems solved by technology

However, the enzyme-free glucose sensor needs to be programmed to control the multi-step potential on the working electrode, which also has some impact on the assembly of the device.

First, the higher negative potential on the working electrode will activate the electrode, which will lead to a larger background current when the glucose in the solution is oxidized, making it more difficult to identify the detection signal

Secondly, hydrogen gas will be generated in the pretreatment step, and the bubbles will attach to the working electrode, and its behavior will change the local glucose concentration, thereby interfering with the detection results. Eliminating these bubbles requires modifying the working electrode with palladium nanoparticle complexes, which will also weaken the detection signal strength.

Finally, the multi-potential steps are controlled by logic circuits and preset programs, but such control methods increase power consumption and device size, which is a serious challenge for long-term wearable devices or installation in tiny spaces

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