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Medicine for treating or preventing human cervical cancer as well as preparation method and application thereof

A drug and cervical technology, applied in the field of medicine, to achieve the effect of novel mechanism of action, small dosage, and no addiction

Inactive Publication Date: 2021-06-01
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on the mechanism of action of anti-tumor drugs based on MDM2-p53 protein interaction signaling pathways and targets.

Method used

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  • Medicine for treating or preventing human cervical cancer as well as preparation method and application thereof
  • Medicine for treating or preventing human cervical cancer as well as preparation method and application thereof
  • Medicine for treating or preventing human cervical cancer as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A preparation method of a medicine for treating or preventing human cervical cancer, specifically:

[0030] Take 50g of the compound 1,5,6-trimethoxy-2,7-dihydroxyphenanthrene, add 150g of fine starch powder, and mix evenly with the method of equal increments, add 5g of talcum powder, 2g of magnesium stearate, mix evenly, and use Granulate with 85% ethanol, dry, whole grain, press into 1000 tablets, 3 times a day, 2 tablets each time.

Embodiment 2

[0032] A preparation method of a medicine for treating or preventing human cervical cancer, specifically:

[0033] Take 50g of the compound 1,5,6-trimethoxy-2,7-dihydroxyphenanthrene, add 200g of fine starch powder, 10g of talcum powder, and 5g of magnesium stearate, mix well, granulate, dry, put into capsules, and prepare Into 1000 capsules, 3 times a day, 2 tablets each time.

Embodiment 3

[0035] A preparation method of a medicine for treating or preventing human cervical cancer, specifically:

[0036]Take 100g of compound 1,5,6-trimethoxy-2,7-dihydroxyphenanthrene, add 250g of microcrystalline cellulose, 50g of cross-linked polyvinylpyrrolidone, mix well, add 90% ethanol to granulate, dry, granulate, Add 10 g of sodium carboxymethyl starch and 5 g of magnesium stearate, mix well, press into 1000 tablets, take 3 times a day, 1 tablet each time.

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Abstract

The invention discloses a medicine for treating or preventing human cervical cancer as well as a preparation method and application thereof, belongs to the technical field of medicines, and particularly relates to a medicine for treating or preventing human cervical cancer based on an MDM2-p53 protein and protein interaction signal channel and a target mechanism as well as a preparation method and application thereof. The invention finds that the action mechanism of the compound 1, 5, 6-trimethoxy-2, 7-dihydroxyphenanthrene is a new mechanism based on an MDM2-p53 protein and protein interaction signal pathway and a target spot. The medicine disclosed by the invention has the characteristics of novel action mechanism, no addiction and small dosage, and has the effect of inhibiting the growth of Hela cells. The IC50 on Hela cells for 48 hours is 0.42 [mu]M. And cell apoptosis can be caused by acting on an MDM2-p53 pathway, and meanwhile, mitochondrial apoptosis is caused.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medicine for treating or preventing human cervical cancer, a preparation method and an application. Background technique [0002] According to the World Health Organization (WTO) report, by the end of this century, cancer will become the number one killer in the world and the biggest obstacle to the extension of human life expectancy. In 2018, there were nearly 18.1 million new cancer cases worldwide, and 9.6 million cancer deaths. According to the statistics of relevant departments in our country, 1.3 million people die of cancer every year, about 1.6 million new cases occur, and the annual economic damage reaches 100 billion yuan. According to the "Latest Ranking of Causes of Death in China" provided by the National Cancer Prevention and Research Office, the death rate of malignant tumors ranks second among all causes of death. Due to the serious pollution of th...

Claims

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Application Information

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IPC IPC(8): A61K31/09A61K9/16A61K47/38A61K47/36A61K47/32A61K47/02A61K36/8984A61P15/00A61P35/00A61K135/00
CPCA61K31/09A61K36/8984A61K9/1652A61K9/1635A61K9/1611A61P15/00A61P35/00
Inventor 张国刚
Owner SHENYANG PHARMA UNIVERSITY
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