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Detection system and detection method for empty suction and blockage of sample needle and reagent needle

A detection method and reagent needle technology are applied in the field of detection systems for sample needles, reagent needle air suction and blocked needles, which can solve the problems of large false alarm rate, missed alarm rate and low accuracy of empty suction and blocked needles, and achieve accurate High rate, low false positive rate, reduced severity effect

Active Publication Date: 2021-05-28
GUANGZHOU KEFEN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing method of empty suction plugging needles does not distinguish samples, which will lead to a large false alarm rate and false negative rate of empty suction blocking needles under different sample conditions, resulting in low accuracy

Method used

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  • Detection system and detection method for empty suction and blockage of sample needle and reagent needle
  • Detection system and detection method for empty suction and blockage of sample needle and reagent needle
  • Detection system and detection method for empty suction and blockage of sample needle and reagent needle

Examples

Experimental program
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Effect test

Embodiment 1

[0058] A detection system for sample needle, reagent needle empty suction and blocked needle, such as figure 1 As shown, it includes a pump valve assembly, a pressure sensor assembly and a needle body connected in sequence, and the pressure sensor assembly is connected with a pressure temperature control device; wherein, the pump valve assembly is used to provide power for the needle body pumping and injecting liquid, and realize Liquid distribution and control; the needle body is connected with the pump valve assembly through an external pipeline for suction and injection of liquid; the pressure sensor assembly is connected with the external pipeline, and the pressure sensor assembly is connected with the external pipeline The liquid in direct contact is used for pressure collection; the pressure temperature control device is connected with the pressure sensor assembly for outputting pressure and controlling the temperature of the pressure sensor assembly. The control of the ...

Embodiment 2

[0063] A detection method for sample needle and reagent needle empty suction, such as image 3 shown, including:

[0064] S101: Acquisition and processing of air suction pressure data. This step is carried out after the instrument is assembled and debugged, the pipeline is completely filled and emptied, and the one-key collection function is set, and the sample liquid is classified according to the concentration gradient, so that the sample needle and reagent can be aspirated for each extraction volume of 5ul, 10ul, etc. Operation, repeat n times for each sample amount, n≥5. During the extraction process of the sample needle and the reagent needle, the pressure sensor 4 collects 1 data every 10 ms, and the collection frequency can be adjusted according to the working conditions. Due to the short pumping time of sample needles and reagent needles, usually below 500ms, coupled with the influence of pump speed control, pipelines, and sensor 4’s own performance, individual jumps...

Embodiment 3

[0079] A kind of detection method of sample needle, reagent needle blocking needle, such as Figure 4 As shown, the steps A101-A106 of this embodiment are basically the same as the empty suction determination steps S101-S106 of the embodiment 2, the difference is that the empty suction operation of steps S101-S106 is replaced by a simulated needle blocking operation. Different samples have different upper limits of the concentration range. According to the sample concentration test data, this embodiment uses honey or sugar water to configure liquids of different concentrations according to the upper limit of the concentration of different samples to simulate the needle blocking experiment and obtain corresponding pressure data. This embodiment specifically includes the following steps:

[0080] A101: Acquisition and processing of needle blocking pressure data. Extraction tests are performed with liquids configured with different sample concentration upper limits to obtain dat...

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Abstract

The invention discloses a detection system and a detection method for empty suction and blockage of a sample needle and a reagent needle, and belongs to the field of in-vitro diagnosis medical detection instruments. The method comprises the following steps: classifying sample liquid according to a concentration gradient, collecting pressure value data of the needle body during empty suction, needle blockage and normal liquid extraction under the same sample adding amount, and converting the pressure value data into comparison parameters; receiving real-time pressure value data of the needle body; converting the real-time pressure value data and comparing with comparison parameters for judgment so that five results of complete air suction, local air suction, complete needle blocking, local needle blocking and normal liquid pumping are obtained; and the feedback system performs corresponding operation according to the judgment result. According to the method, the samples are classified according to the concentration gradient, the original data are collected, the judgment of air suction needle blockage of different samples under the condition of the same sample adding amount is realized, direct judgment without classification is avoided, and the accuracy of air suction needle blockage judgment is improved; and the reliability of clinical detection results of the instrument is improved. According to the method, empty suction and needle blocking judgment of the extremely small liquid amount is achieved, the accuracy rate is high, and the false alarm rate is low.

Description

technical field [0001] The invention belongs to the field of in vitro diagnostic medical detection instruments, and in particular relates to a detection system and method for sample needles and reagent needles for air suction and blocking needles. Background technique [0002] In recent years, domestic in vitro diagnostic medical instruments have developed rapidly, the process of import substitution has accelerated, and the number of domestic manufacturers has increased rapidly. In vitro diagnostic testing instruments are used in the detection of human samples, requiring high precision, sensitive response, and good repeatability. The quantitative extraction accuracy of sample needles and reagents for samples and reagents will directly affect the test results and greatly affect the detection performance of an instrument. Therefore, in vitro testing instruments must strictly control the quantitative extraction of sample needles and reagent needles. There are many factors tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/00
CPCG01N33/00
Inventor 薛蛟生宋德键
Owner GUANGZHOU KEFEN BIOTECH CO LTD
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