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Preparation method of Cu2O yolk shell nanospheres for non-enzymatic blood glucose detection

A blood sugar detection, egg yolk shell technology, applied in the field of non-enzymatic glucose sensor, can solve the problems of narrow linear range and low sensitivity

Active Publication Date: 2021-05-28
NORTHEASTERN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the obtained material is applied in the field of non-enzymatic glucose sensor, it exhibits excellent performance, solving the problem of traditional Cu 2 Low sensitivity and narrow linear range of O-based non-enzymatic glucose sensor

Method used

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  • Preparation method of Cu2O yolk shell nanospheres for non-enzymatic blood glucose detection
  • Preparation method of Cu2O yolk shell nanospheres for non-enzymatic blood glucose detection
  • Preparation method of Cu2O yolk shell nanospheres for non-enzymatic blood glucose detection

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Experimental program
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Effect test

Embodiment 1

[0023] A method for preparing Cu2O yolk shell nanospheres for non-enzyme blood glucose detection, comprising the steps of:

[0024] (1) Configure the reaction solution

[0025] First weigh 0.05 mmoles of copper sulfate, then weigh the ingredients respectively according to the molar ratio of copper sulfate: hexadecyltrimethylammonium bromide: sodium hydroxide: sodium ascorbate, and mix copper sulfate and Cetyltrimethylammonium bromide was added to a beaker containing 50ml of deionized water, sodium hydroxide and sodium ascorbate were respectively added to a beaker containing 50ml of deionized water, fully stirred to obtain a uniform solution;

[0026] (2) Preparation of Cu 2 O egg yolk shell nanosphere

[0027] Add 10ml, 9ml, 9ml, 9ml, 9ml of the mixed solution of copper sulfate and cetyltrimethylammonium bromide into five 25ml beakers respectively, and mark them as A-E respectively; take 0.2ml of sodium ascorbate solution Add dropwise into beaker A, shake for 10s, add 0.4ml...

Embodiment 2

[0031] A method for preparing Cu2O yolk shell nanospheres for non-enzyme blood glucose detection, comprising the steps of:

[0032] (1) Configure the reaction solution

[0033] First weigh 0.05 mmoles of copper sulfate, then weigh the ingredients respectively according to the molar ratio of copper sulfate: hexadecyltrimethylammonium bromide: sodium hydroxide: sodium ascorbate 1:5:100:20, and mix copper sulfate and Cetyltrimethylammonium bromide was added to a beaker containing 50ml of deionized water, sodium hydroxide and sodium ascorbate were respectively added to a beaker containing 50ml of deionized water, fully stirred to obtain a uniform solution;

[0034] (2) Preparation of Cu 2 O egg yolk shell nanosphere

[0035] Add the mixed solutions of copper sulfate and cetyltrimethylammonium bromide into five 25ml beakers respectively according to 10ml, 9ml, 9ml, 9ml, and 9ml, and mark them as A-E respectively; take 0.25ml of sodium ascorbate solution Add dropwise into beaker A,...

Embodiment 3

[0040] A kind of Cu for non-enzymatic blood glucose detection 2 The preparation method of O egg yolk shell nanosphere, comprises the steps:

[0041] (1) Configure the reaction solution

[0042] First weigh 0.05 mmoles of copper sulfate, then weigh the ingredients respectively according to the molar ratio of copper sulfate: hexadecyltrimethylammonium bromide: sodium hydroxide: sodium ascorbate 1:5.5:110:25, and mix copper sulfate and Cetyltrimethylammonium bromide was added to a beaker containing 50ml of deionized water, sodium hydroxide and sodium ascorbate were respectively added to a beaker containing 50ml of deionized water, fully stirred to obtain a uniform solution;

[0043] (2) Preparation of Cu 2 O egg yolk shell nanosphere

[0044] Add 10ml, 9ml, 9ml, 9ml, 9ml of the mixed solution of copper sulfate and cetyltrimethylammonium bromide into five 25ml beakers, and mark them as A-E respectively; take 0.3ml of sodium ascorbate solution Add dropwise into beaker A, shake ...

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Abstract

The invention relates to the technical field of non-enzymatic glucose sensors, in particular to a preparation method of Cu2O yolk shell nanospheres for non-enzymatic blood glucose detection, which comprises the following steps: preparing a reaction solution, then preparing the Cu2O yolk shell nanospheres, and finally purifying the Cu2O yolk shell nanospheres. A cetyl trimethyl ammonium bromide microemulsion system is utilized to obtain the Cu2O nanosphere with the yolk shell structure. When the obtained material is applied to the field of non-enzymatic glucose sensors, excellent performance is shown, and the problems that a traditional Cu2O-based non-enzymatic glucose sensor is low in sensitivity and narrow in linear range are solved.

Description

technical field [0001] The invention relates to the technical field of non-enzymatic glucose sensors, in particular to a Cu sensor for non-enzymatic blood sugar detection 2 The preparation method of O egg yolk shell nanosphere. Background technique [0002] Diabetes often leads to a series of life-threatening diseases, such as high blood pressure, heart disease, blindness, kidney failure, etc. As of 2020, the number of diabetic patients in the world has exceeded 300 million, and the number of diabetic patients in China is as high as 114 million. As we all know, the occurrence of diabetes is closely related to high blood sugar levels. Therefore, the purpose of early prevention and early detection can be achieved through real-time measurement of blood sugar. So it is necessary to study a glucose sensor with high sensitivity, wide linear range, good stability and selectivity. [0003] Currently commonly used glucose sensors are mainly divided into two categories: one is an e...

Claims

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Application Information

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IPC IPC(8): G01N27/26
CPCG01N27/26
Inventor 祁阳刘文彬
Owner NORTHEASTERN UNIV
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